Transgenerational inheritance of meiotic silencing - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Anna Naumova

Supervisor's Email: anna.naoumova [at]

Supervisor's Phone: 514-934-1934 x 35906

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Transgenerational inheritance of meiotic silencing

Project description (50-100 words suggested): During meiosis, homologous chromosomes pair, synapse and recombine. Chromosomal anomalies interfere with normal synapsis and trigger epigenetic silencing of unsynapsed regions. Hence genes located in unsynapsed regions are not expressed in meiotic prophase I. However, it remains unknown if the silencing marks are transmitted to offpring. To find out if epigenetic marks of meiotic silencing are transmitted to the next generation, we will analyze gene expression in embryos from parents that carry chromosomal translocations.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Other project information: The project includes handling mice, collecting mouse embryos, extracting RNA and expression analysis.

Project status: This project is open to applicant.

How students can apply / Next steps: For HGEN: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Biohazardous substances; Handling chemicals.