Biomarkers for pediatric brain cancers - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Nada Jabado

Supervisor's Email: nada.jabado [at] mcgill.ca

Supervisor's Phone: 514-934-1934 ext 76163

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Fall 2015

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Biomarkers for pediatric brain cancers

Project description (50-100 words suggested): Pediatric primary brain tumors such as high grade astrocytomas (HGA) are universally deadly primary brain tumors, especially when acquired specific mutations in histone (H3) genes within the cancer cells are present. The candidate will be involved in detection of molecular markers (biomarkers) in plasma of children with pediatric HGA and evaluate the sensitivity and selectivity of the detection of circulating/cell free nuclei acids of mutant H3 fragments (cfDNA) in plasma of patients with HGA. Because plasma of these patients is rare and precious, primary human cancer cells will be used as a model system.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.