Gene expression signatures underlying bone healing - HGEN 396 Undergraduate Research Project Application Form

Supervisor's Name: Elin Grundberg

Supervisor's Email: elin.grundberg [at]

Supervisor's Phone:

Supervisor's Website:

Supervisor's department: Human Genetics

Course number: HGEN 396 (Human Genetics)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Gene expression signatures underlying bone healing

Project description (50-100 words suggested): Treatment of bone defects presents a significant burden to the medical community due to the challenge of repair and limited reconstructive options. The Masquelet Technique (MT) is a clinically effective approach where a specific membrane is placed in the defect to help restore form and function. However, the physiology of the healing is not well understood but hypothesized that the membrane is biologically active and has bone-forming potential. Here, we are using multiple animal models undergoing bone surgery with various types of membranes for next-generation transcriptomic studies for the identification of gene expression signatures underlying the induced bone healing process.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on an evaluation of laboratory (or equivalent) performance (40%), a final written report (50%), and an oral presentation (10%) by the supervisor. Details of the evaluation scheme will be provided by HGEN to supervisors and applicants.

Other project information: This project involves both wet lab (RNA isolation, 
library preparation) and computational work (data analysis).

Project status: This project is taken.

How students can apply / Next steps: After all of the parts of this application forms are completed and the hard copy is signed by the professor and the student, bring the application form and a copy of your unofficial transcript to the Department of Human Genetics (to the attention of Dr. Patricia N. Tonin, Stewart Biology Building N5.13) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Animal subjects; Human subjects.