Mitochondrial homeostasis in disease - ANAT 396 Undergraduate Research Project Application Form

Supervisor's Name: Heidi McBride

Supervisor's Email: heidi.mcbride [at] mcgill.ca

Supervisor's Phone: 514 398 1808

Supervisor's Website: mcbridelab.org

Supervisor's department: Anatomy and Cell Biology

Course number: ANAT 396 (Anatomy and Cell Biology)

Term: Fall 2015-2016

Project start date: Friday, September 4, 2015

Project end date: Monday, December 7, 2015

Project title: Mitochondrial homeostasis in disease

Project description (50-100 words suggested): There are 4 core pathways to remove or degrade damaged mitochondrial content, but the level of redundancy and compensation between pathways remains unknown. Recently we identified cargo-selected mitochondrial derived vesicles that carry oxidized protein and lipid to the late endosome.  However, it is unclear what the contribution of this pathway is in cells where mitochondrial function is compromised.  We will examine the role of MDVs in diseased human fibroblasts with mutations in factors required for mitochondrial translation. Cells will be grown and treated with stressors in order to quantify the MDVs response.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Report: 50%' Lab presentation: 25%; Lab performance: 25%.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances