Supervisor's Name: Mark Wainberg
Supervisor's Email: mark.wainberg [at] mcgill.ca
Supervisor's Phone: (514) 340-8307
Supervisor's Website: http://www.ladydavis.ca/en/markwainberg
Supervisor's department: Microbiology and Immunology
Course number: MIMM 396 (Microbiology)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Studies on HIV Integrase Drug Resistance
Project description (50-100 words suggested): The candidate will purify and characterize the enzymatic properties of Integrase enzymes that contain defined drug resistance substitutions and will compare these activities to that of wild-type enzyme. Two different methods will be used. One is a 3' synthetase assay and the other is an integrase strand transfer assay. Efforts will also be made to understand the results in the context of a 3-dimensional structure of the Integrase protein.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final report: 70%; Lab participation: 30%
Project status: This project is taken.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.