Role of TGFb signaling in human cancer - MIMM 396 Undergraduate Research Project Application Form

Supervisor's Name: Jean-Jacques Lebrun

Supervisor's Email: JJ.Lebrun [at] mcgill.ca

Supervisor's Phone: 5149341934 x34846

Supervisor's Website:

Supervisor's department: Medicine

Course number: MIMM 396 (Microbiology)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Role of TGFb signaling in human cancer

Project description (50-100 words suggested): Dr Lebrun laboratory is investigating the role and mechanism of action of the transforming growth factor-β (TGFβ) in the regulation of tumor formation and cancer progression, with a long term goal of developing novel therapies against metastatic cancer. On one hand TGFB exerts tumor suppressive effects in normal cells and in early carcinomas whereas in advanced cancer TGFβ has pro-migratory and pro-invasive functions. This project will aim at defining the molecular mechanism underlying the pro-metastatic effect of this cytokine in invasive cancers, focusing on breast cancer with the goal of designing novel anti-TGFβ signaling therapies against cancer.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Project status: This project is taken.

Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Prof. Gregory Marczynski during office hours, who will review/approve as the course coordinator for MIMM 396 (Microbiology) or MIMM 397 (Immunology).

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.