Alterations in Deep cerebellar nuclei in a mouse model of SCA6 - BIOL 396 Undergraduate Research Project Application Form

Supervisor's Name: Alanna Watt

Supervisor's Email: alanna.watt [at] mcgill.ca

Supervisor's Phone: 2806

Supervisor's Website:

Supervisor's department: Biology

Course number: BIOL 396 (Biology)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Alterations in Deep cerebellar nuclei in a mouse model of SCA6

Project description (50-100 words suggested): Spinocerebellar ataxia type 6 (SCA6) is a devastating neurodegenerative motor disease that is caused by a mutation in a P/Q type calcium channel that is highly expressed in the cerebellum. Degeneration of neurons in the deep cerebellar nuclei (DCN) has been observed in some human patients, and our preliminary studies with a mouse model of SCA6 suggest that DCN cells degenerate after ataxia onset. We will determine the time course of degeneration of DCN neurons and will determine whether this correlates with disease onset.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Lab work: 50%; Final report: 50%

Project status: This project is taken. The professor has no more '396' projects this term.

How students can apply / Next steps: After all parts of this application form are completed, and the hard copy is signed by the professor and the student, bring this application form and your unofficial transcript to Susan Gabe (Stewart Biology W3/25B) or Nancy Nelson (W3/25) during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.