Supervisor's Name: Jason Young
Supervisor's Email: jason.young2 [at] mcgill.ca
Supervisor's Phone: 514-398-2006
Supervisor's department: Biochemistry
Course number: BIOC 396 (Biochemistry)
Term: Winter 2013-2014
Project start date: Monday, January 6, 2014
Project end date: Friday, April 11, 2014
Project title: Effects of Hsp70 mutations on function and CFTR trafficking
Project description (50-100 words suggested): Cystic Fibrosis is a genetically driven disease with no known cure, and an ongoing medical challenge. The disease is caused by loss of function of the cystic fibrosis transmembrane conductance regulator, CFTR, a chloride channel critical to maintaining hydration in the lung airways and pancreas. Mutations in CFTR cause it to become misfolded and degraded at the endoplasmic reticulum, instead of trafficking to the cell surface to function. Surprisingly little is known about the chaperone mechanisms that assist wild-type and mutant CFTR folding, particularly by the essential chaperone Hsp70. Our project will characterize mutants of Hsp70 expected to have defects in various biochemical mechanisms, to determine effects on Hsp70 function and CFTR trafficking.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): 50% report, 50% performance
Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves NEITHER animal subjects, nor human subjects, nor biohazardous substances, nor radioactive materials, nor handling chemicals, nor using lasers.