Quantitative assessment of neuroanatomical correlates of pathology in Alzheimer's Disease mouse models - ANAT 396 Undergraduate Research Project Application Form

Supervisor's Name: Thomas Stroh

Supervisor's Email: thomas.stroh [at] mcgill.ca

Supervisor's Phone: 514-398-2719

Supervisor's Website:

Supervisor's department: Anatomy and Cell Biology; Neurology and Neurosurgery

Course number: ANAT 396 (Anatomy and Cell Biology)

Term: Winter 2013-2014

Project start date: Monday, January 6, 2014

Project end date: Friday, April 11, 2014

Project title: Quantitative assessment of neuroanatomical correlates of pathology in Alzheimer's Disease mouse models

Project description (50-100 words suggested): In transgenic mouse models of Alzheimer's disease (AD) we will study the impact of the angiotensin type II receptor subtype AT2 in the brain on the manifestation and progression of AD as measured by the expression pattern the microtubule-associated protein tau and the histoarchitecture and volume of the dorsal hippocampus. To this end, the student will employ standard neuroanatomical techniques such as cryosectioning, cresyl violet staining and immunostaining of frozen sections. The histological parameters of the thus produced samples will be quantitatively analyzed using high-resolving microscopy and unbiased stereology. The student will thus learn key techniques of quantitative neuroanatomy.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information: The brain tissue is already present in fixed and deep frozen form in the laboratory. For the student conducting the research that means there is no requirement to conduct animal procedures.

Project status: This project is taken. The professor has no more '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Handling chemicals.