'Impact of bronchopulmonary dysplasia on brain development' - NSCI 396 Undergraduate Research Project Application Form

Supervisor's Name: Pia Wintermark

Supervisor's Email: pia.wintermark [at] mcgill.ca

Supervisor's Phone: 514-412-4452

Supervisor's Website: www.neobrainlab.org

Supervisor's department: Pediatrics (+ Neurology/Neurosurgery)

Course number: NSCI 396 (Neuroscience)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Impact of bronchopulmonary dysplasia on brain development

Project description (50-100 words suggested): Bronchopulmonary dysplasia (BPD) is a severe chronic lung disease developing in premature newborns exposed to prolonged mechanical ventilation. Our hypothesis is that oxygen toxicity  (hyperoxia) associated with mechanical ventilation (causing the BPD) is also the responsible mechanism of damage to the developing brain in these patients. We will use a known rodent model of BPD. We will perform histological and immunohistochemical analyses to compare infarct volume, neurogenesis and angiogenesis between rats brains exposed or not to hyperoxia. This will provide a better understanding of why brain injury develop in these premature newborns exposed to prolonged mechanical ventilation.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information:The proposed project will allow the assigned student to develop skills in the field of neonatal neurology. The student will review pertinent literature on the research topic. She will get the necessary training to comply with McGill regulations on animal experimentation. She will learn about the animal model. Initially in collaboration with research assistant or senior graduate students, she will learn the different techniques required to perform this experiment. Additionally to the above tasks, the student will present her own data to lab meeting and write an experimental report. If experimental data obtained warrants it, she will write up an abstract to be presented at an important annual meeting or to be submitted as a scientific paper.

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves animal subjects.