'Investigating the Role of MET Signaling in Triple Negative Breast Cancers' - BIOC 396 Undergraduate Research Project Application Form

Supervisor's Name: Morag Park

Supervisor's Email: morag.park [at] mcgill.ca

Supervisor's Phone: 514-398-5749

Supervisor's Website: http://www.mcgill.ca/biochemistry/about-us/department/faculty-members/park

Supervisor's department: Biochemistry

Supervisor's department (if none of the above):

Course number: BIOC 396 (Biochemistry)

Term: Fall 2013-2014

Project start date: Tuesday, September 3, 2013

Project end date: Tuesday, December 3, 2013

Project title: Investigating the Role of MET Signaling in Triple Negative Breast Cancers

Project description (50-100 words suggested): Triple negative breast cancers (TNBC) lack expression of therapeutic targets HER2 and estrogen receptors and are correlated with poor prognosis. The MET receptor tyrosine kinase (RTK) is a cell surface protein that, upon activation by its ligand hepatocyte growth factor (HGF), initiates a program of cell survival, migration, and invasive growth. Elevated levels of MET are detected in 15-20% of breast cancers and are associated with TNBC. The goal of this project is to investigate the role of MET signaling in TNBC and to identify cooperating pathways involved in tumour development.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): (The final report must be worth at least 50% of final grade): Research report 50%; Laboratory performance 50%

Project status: This project is taken; however students may contact the professor to discuss other possible '396' projects this term.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances; Handling chemicals.