'Dynamical Effects of Potassium Channel Blockers on Embryonic Ventricular Myocytes' - MATH 396 Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Please review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102. The Office for Undergraduate Research in Science will later post the project online, indicating whether the project is open for students to apply or taken.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964

Supervisor's Name: Leon Glass

Supervisor's Email: glass [at] cnd.mcgill.ca

Supervisor's Phone: 514-398-4338

Supervisor's Website: http://www.medicine.mcgill.ca/physio/glasslab/

Supervisor's department: Cardiac Physiology

Course number: MATH396

Term: Fall 2011-2012

Project start date: September 2011

Project end date: December 2011

Project title: Dynamical Effects of Potassium Channel Blockers on Embryonic Ventricular Myocytes

Project description:

Our laboratory is studying the rhythms induced in spherical aggregates and monolayers of embryonic chick heart cells in tissue culture by addition of drugs. Data obtained to date indicates complex changes of dynamics (bifurcations) as the concentrations of drugs and duration of the drug administration are varied. During this research project, Mr. Michael Rozenbojm will learn how to make the tissue cultures and also learn how to carry out recordings of the activity using optical recording using motion artifact. In view of the important roles of calcium in cardiac tissue and in cardiac medications, he will study the role of drugs that block that calcium channels. We hypothesize that as the concentration of the drugs increase, there will be emergence of abnormal rhythms. In addition to the collection of data, he will also carry out theoretical modeling of the bifurcations induced by the addition of calcium channel drugs in theoretical models of the cardiac tissue with a view of understanding the mechanisms of origin of abnormal rhythms. This project involves developing skills in nonlinear dynamics of differential equations as well as experimental skills in handling of living tissue and optical recording. In carrying out this project, Mr. Rozenbojm will interact with other students in the laboratory as well as Professor Leon Glass. He will be expected to attend laboratory meetings, and to prepare written and oral presentations of the work he carries out during the semester.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme: Submission of an Oral Presentation and Paper.

Project status - This project is: Taken.

How students can apply: Bring this application form and your advising transcript to me during office hours.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. Which of the following, if any, is involved? Animal subjects; Biohazardous substances; Handling chemicals.

Student's Name:

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Student's Level (U0 / U1 / U2 / U3):

Student signature - I have not applied for another '396' course in this term: 

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