'Cell adhesion and epithelial organization in Drosophila' - BIOL 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102. The Office for Undergraduate Research in Science will later post the project online at www.mcgill.ca/science/research/ours/396/listing, indicating whether the project is open for students to apply or taken.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964

Supervisor's Name: Laura Nilson

Supervisor's Email: laura.nilson [at] mcgill.ca

Supervisor's Phone: 514 398-6448

Supervisor's Website:

Supervisor's department: Biology

Course number: BIOL396 (Biology)

Term: Fall 2011-2012

Project start date: Wednesday, September 1, 2011

Project end date: Tuesday, December 6, 2011

Project title: Cell adhesion and epithelial organization in Drosophila.

Project description: The student will investigate the role of cell adhesion in regulating epithelial cell shape and organization, using Drosophila as a model system. My lab has identified a role for the homophilic adhesion molecule, Echinoid, in orchestrating epithelial morphogenesis in the Drosophila ovary and embryo. We are interested in understanding whether the extracellular domain of Echinoid plays a specific role in this process, or if any extracellular domain with homophilic binding properties can substitute. To address this question, the student will use molecular cloning techniques to generate a chimeric molecule consisting of the extracellular domain of the cell adhesion molecule E-Cadherin fused to the transmembrane and intracellular domains of Echinoid. The student will then generate transgenic flies bearing this novel construct, in order to test its function in vivo.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Grading scheme (The final report must be worth at least 50% of final grade): Final grade will be based on laboratory performance (50%) and final report (50%).

Project status - This project is: Taken. The professor has no more '396' projects this term.

How students can apply: N/A; this project is filled.

Ethics, safety, and training: Supervisors are responsible for the ethics and safety compliance of undergraduate students. This project involves: Biohazardous substances

Student's Name:

Student's McGill ID:

Student's Email (first.last [at] mail.mcgill.ca):

Student's Phone:

Student's Program:

Student's Level (U0 / U1 / U2 / U3):

Student's signature - I have not applied for another '396' course in this term:

Supervisor's signature - I give my permission for the student identified above to register for this project under my supervision:

Date:

Unit chair/director/designate's name:

Unit chair/director/designate's signature - I certify that this project conforms to departmental requirements for 396 courses:

Date: