'The role of Claudin-16 and Claudin-19 in nephron formation' - ANAT 396 Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Please print and review this form. Complete or correct the sections, as applicable, from "Supervisor's Name" to "Ethics, safety, and training". Please sign and date near the bottom ("Supervisor's signature").

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it from www.mcgill.ca/science/research/ours/396 after it has been posted. Either way, print and review this form. Complete or correct the sections, from "Student's Name" to "Student's Level", and sign ("Student signature). Ask your supervisor to sign her/his section near the bottom. Take it to the department corresponding to the course number; this may or may not be your own department. Do not register for a '396' course on Minerva until  you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, please notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102. The Office for Undergraduate Research in Science will later post the project online at www.mcgill.ca/science/research/ours/396/listing, indicating whether the project is open for students to apply or taken.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964

Supervisor's Name: Indra Gupta
Supervisor's Email: indra.gupta [at] muhc.mcgill.ca
Supervisor's Phone: 514-412-4400 ext 23539
Supervisor's Website:
Supervisor's department: Human Genetics, Experimental Medicine and Pediatrics
Course number: ANAT396 (Anatomy and Cell Biology)
Term: Fall 2011-2012
Project start date: Wednesday, September 1, 2011
Project end date: Tuesday, December 6, 2011
Project title: The role of Claudin-16 and Claudin-19 in nephron formation
Project description: Humans with mutations in Claudin-16 and Claudin-19 have hypercalciuria, hypermagnesiuria and they develop renal failure in adolescence. Our expression data in the mouse indicates that both of these claudins are expressed during mouse embryonic kidney development.  Their expression pattern suggests that these claudins may be important for nephron formation. The student will be involved in analysing kidneys derived from mouse models where claudin-16 and claudin-19 have been knocked down.  He will assess where there is a defect in nephron formation in kidneys collected from newborn mice.  He will learn about kidney development, claudins, and gain important skills in genotyping mice, dissecting kidneys, embedding kidneys, sectioning, staining tissues and counting nephrons.  He will be directly supervised by a graduate student in the lab.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).
Project status - This project is: Taken. The professor has no more '396' projects this term.
Ethics, safety, and training: Supervisors are responsible for the ethics and 
safety compliance of undergraduate students. Which of the following, if any, 
is involved?
  - Animal subjects
  - Biohazardous substances
Student's Name:
Student's McGill ID:
Student's Email (first.last [at] mail.mcgill.ca):
Student's Phone:
Student's Program:
Student's Level (U0 / U1 / U2 / U3): U2
Student's signature - I have not applied for another '396' course in this 
Supervisor's signature - I give my permission for the student identified 
above to register for this project under my supervision:
Date: Aug. 29, 2011
Unit chair/director/designate's name:
Unit chair/director/designate's signature - I certify that this project 
conforms to departmental requirements for 396 courses: