'Role of Autophagy in the Regulation of Muscle Mass in Post-operative Cardiac Surgical Patients.' Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Dr. Sheldon Magder
Email: sheldon.magder [at] muhc.mcgill.ca (sheldon dot magder at muhc dot mcgill dot ca)
Supervisor's department: Physiology
Course number: PHGY396 (Physiology)
Term: Winter 2010-2011
Project start date: Tuesday, January 4, 2011
Project end date: Friday, April 8, 2011
Project title: Role of Autophagy in the Regulation of Muscle Mass in Post-operative Cardiac Surgical Patients
Project description: Normal muscle function is critical for post-operative ambulation and protection of the airway. Muscle also is the major source of amino-acids which are needed by other organs during catabolic periods. Muscle mass is maintained by a balance between protein synthesis (anabolism) and protein degradation (catabolism). When degradation exceeds production, muscles shrink (atrophy). Catabolic processes require systematic degradation, removal and recycling of the products. A component in this process is called autophagy and its failure can lead to tissue loss. A failure of autophagy also has been associated with the aging process. The aims of this project are
1. determine if autophagy is activated as part of the normal adaptive response to surgical stress
2. establish if activation of autophagy is decreased in the elderly patient (>70 years of age); thus limiting their potential for recovery
3. verify if decreased muscle fibre area and satelite cells in elderly patients limit their recovery potential.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): 50% lab work and 50% final written report
Other project information:
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
Ethics, safety, and training
Which of the following, if any, is involved? One or more of the following
Animal subjects [ ]
Human subjects [ ]
Biohazardous substances [ ]
Radioactive materials [ ]
Handling chemicals [x]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:  
Email (first.last [at] mail.mcgill.ca):  
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):  
Level (U0 / U1 / U2 / U3):  
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: