'T cell modulation by astroglial factors' Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Amit Bar-Or
Email: amit.bar-or [at] mcgill.ca (amit dot bar-or at mcgill dot ca)
Supervisor's department: Microbiology and Immunology
Supervisor's department (if none of the above) Neurology and Neurosurgery
Course number: MIMM397 (Immunology)
Term: Winter 2010-2011
Project start date: January 04 2011
Project end date: April 08 2011
Project title: T cell modulation by astroglial factors
Project description: Targeting pathologic TH1 and Th17 responses in the periphery of patients with multiple sclerosis is only partially effective, as patients continue to experience disease progression. Ongoing activation of Th1 and Th17 cells within the central nervous system (CNS) may contribute to such ongoing injury. Thus, understanding what regulates T cell differentiation (Th1, Th2, Th17) within the CNS is important. Our lab's preliminary data suggests that products of CNS glial cells preferentially drives Th17 responses. The proposed project will investigate how human astrocytes, through contact dependent and independent mechanisms, influence T cell differentiation using established and adapted protocols for isolating glial cells, and assessing their effects (co-culture, transwell) on activated CD4 T cell cytokine responses (using flow cytometry)
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%)
Other project information:
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? One or more of the following
Animal subjects [ ]
Human subjects [x]
Biohazardous substances [ ]
Radioactive materials [ ]
Handling chemicals [ ]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:  
Email (first.last [at] mail.mcgill.ca):  
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):  
Level (U0 / U1 / U2 / U3):  
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: