'PARP inhibitor sensitization of colon cancer cell lines to DNA damaging agents'. Undergraduate Research Project Application Form.

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.)
DONE

INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission. Have a discussion with your supervisor about time/work expectations, keeping in mind that this is a 3-credit course (roughly, 10 hours per week for 12 weeks). Remember that a '396' course is an elective.

INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science.

QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.

SECTION A: SUPERVISOR INFORMATION

Name: Lawrence Panasci

Email: lpanasci [at] hotmail.com (lpanasci at hotmail dot ca)

Phone: 514-340-8248

Website:

Supervisor's department: None of the above

Supervisor's department (if none of the above) Oncology/experimental medicine

Course number: ANAT396 (Anatomy and Cell Biology)

SECTION B: PROJECT INFORMATION

Term: Winter 2010-2011

Project start date: January 4, 2011

Project end date: Friday april 8, 2011

Project title: PARP inhibitor sensitization of colon cancer cell lines to DNA damaging agents

Project description: My laboratory has been investigating the ability of various compounds to inhibit DNA repair and sensitize CLL(chronic lymphocytic leukemia lymphocytes) and cancer cell lines for many years. Inhibition of PARP may not only inhibit base excision repair but also alternative nonhomologous endjoining(alt-NHEJ). In this context, utilization of ABT-888 to inhibit these pathways will be an initial step to perhaps combining this agent with other DNA repair inhibitors to sensitize cancer cells to various chemotherapeutic agents.

Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.

Other prerequisite, if applicable:

Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).

Other project information:

Project status - This project is: Taken. The professor has no more '396' projects this term.

How students can apply: N/A; this project is filled.

If other, please specify:

Ethics, safety, and training

Which of the following, if any, is involved? One or more of the following

Animal subjects [ ]

Human subjects [ ]

Biohazardous substances [x]

Radioactive materials [ ]

Handling chemicals [ ]

Using lasers [ ]

Supervisors are responsible for the ethics and safety compliance of undergraduate students.

SECTION C: STUDENT INFORMATION

Do not complete this section unless/until the student is identified.

Name:

McGill ID:

Email (first.last [at] mail.mcgill.ca):

Phone:

Program (E.g., B.Sc. Maj. Chem. Min. Biol.):

Level (U0 / U1 / U2 / U3):

Student signature - I have not applied for another '396' course in this term:

SECTION D: APPROVALS.

Do not complete this section unless/until the student is identified.

Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.

Supervisor's signature: Lawrence Panasci

Date: Jan 5, 2011

Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.

Unit chair/director/designate's name:

Unit chair/director/designate's signature:

Date: