ANAT 396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Dr. Morag Park
Email: morag.park [at]
Phone: 514-398-5749
Supervisor's department: Biochemistry
Supervisor's department (if none of the above)  
Course number: ANAT396 (Anatomy and Cell Biology)
Term: Winter 2008-2009
Project start date: January 5 2009
Project end date: April 14th 2009
Project title: Characterizing the structural regions required for Cbl loss downstream from the Met Receptor Tyrosine Kinase
Project description: The Cbl family of proteins functions as tumour suppressors by negatively regulating signals of growth factor receptors. Negative regulation of receptor tyrosine kinases by Cbl is an important process, and loss or inhibition of Cbl has been demonstrated to be a transforming event. Our lab has shown loss of Cbl downstream of the Met receptor tyrosine kinase. Previous work has determined that a functional RING finger and the C-terminal half of Cbl is required for Cbl loss. The aim of the project is to ascertain the specific region or regions of the C-terminal half of Cbl required for Met-mediated Cbl loss. The project will utilize site-directed mutagenesis to create truncated constructs, and will co-express the constructs with Met to determine which portion of Cbl plays a role in Cbl stability. The significance of this project is to further understand Cbl's role as a tumor suppressor, as Cbl loss has been shown to be a transforming event.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): TBC
Other project information:
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? None
Animal subjects [ ]
Human subjects [ ]
Biohazardous substances [ ]
Radioactive materials [ ]
Handling chemicals [ ]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:  
Email (first.last [at]  
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):  
Level (U0 / U1 / U2 / U3):
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: