396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Dr. Craig Mandato
Email: craig.mandato [at] mcgill.ca
Phone: 514-398-5349
Supervisor's department: Anatomy and Cell Biology
Supervisor's department (if none of the above)
Course number: ANAT396 (Anatomy and Cell Biology)
Term: Winter 2008-2009
Project start date: January 19, 2009
Project end date: April 14, 2009
Project title: Extent of, risk factors and outcome of fluid overload after child heart surgery
Project description: Children undergoing cardiac surgery are at risk for several post-operative complications. One of the most common complications is acute kidney injury, which leads to the retention of fluids or edema. The retention of fluids, as a result of a water excretion defect, is referred to as "fluid overload" (FO). FO is associated with respiratory difficulty, limitations in nutrition and with higher mortality in other critically ill populations. While anecdotally, FO is a major problem in children after heart surgery, the extent to which this occurs in this fragile patient population is unclear. The reason it is important to decipher how severe fluid overload is and to what extent it is associated with worse outcome is to better target and define fluid management strategies. Our underlying hypotheses are that FO development is substantial after pediatric heart surgery and that FO is associated with longer length of stay, worse respiratory function (defined by the oxygenation index) and longer ventilatory support need. We will 1) determine the extent of fluid overload occurring in children having heart surgery and characterize the time pattern of FO development; 2) Evaluate the risk factors of worse fluid overload development; 3) Determine if fluid overload is independently associated with the stated outcomes. Data on clinical, fluid, laboratory and respiratory parameters during post-surgical intensive care unit admission will be collected retrospectively from patient medical charts and recorded onto a standardized case report form. The student will actively participate in this data collection. The student will then assist in entering the data into a pre-formed database (in EXCEL and/or ACCESS). Once the data collection is complete, the student will perform appropriate statistical analyses (both univariate and multivariate) under the guidance of the supervisor, to answer the main study questions. The student and supervisor will interpret the results and discuss the findings. The student will then write up a report, including a moerately detailed literature review on this topic (which will include pathophysiology of fluid overload and respiratory difficulty), the methodology, results and a discussion.
Prerequisite: 1 term completed at McGill + CGPA ≥ 3.0; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): Final paper 50%; Data collection 20%; Background reading and knowledge of statistics 20%; Data analysis 10%
Other project information: This project will be co-supervised by Dr. Michael Zappitelli ( mzaprdr [at] yahoo.ca (mzaprdr) at yahoo dot ca), Dept. of Nephrology, MCH, 514-406-2938.
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? None
Animal subjects [ ]
Human subjects [ ]
Biohazardous substances [ ]
Radioactive materials [ ]
Handling chemicals [ ]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:
Email (first.last [at] mail.mcgill.ca):
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):
Level (U0 / U1 / U2 / U3):
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: