396 Undergraduate Research Project Application Form

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.)DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Nathalie Lamarche-Vane
Email: Nathalie.Lamarche [at] mcgill.ca (Nathalie.Lamarche) -at-mcgill.ca
Phone: 514-398-1784
Supervisor's department: Anatomy and Cell Biology
Supervisor's department (if none of the above)  
Course number: ANAT396 (Anatomy and Cell Biology)
Term: Winter 2008-2009
Project start date: January 5, 2009
Project end date: April 14, 2009
Project title: Determination of the intracellular domain of the netrin-1 receptor DCC in neurite outgrowth
Project description: Netrins are a small family of secreted proteins that function as tropic cues directing cell and axon migration during neural development. Netrins are bifunctional molecules attracting and repelling different classes of axons. In vertebrates, growth cone attraction mediated by netrin-1 involves the netrin-1 receptor DCC (deleted in colorectal cancer) whereas repulsion involves the UNC5 proteins. However, UNC5-mediated repulsion may require the function of DCC proteins in some cases. We have shown that the expression of DCC in N1E-115 neuroblastoma cells induces the formation of neurites in a netrin-1-dependent manner. We have constructed deletion mutant proteins of the cytoplasmic domain of DCC. The student will examine the expression of these different mutant proteins in N1E-115 cells and will determine the ability of these proteins to induce neurite outgrowth. This study will delineate the intracellular domains required for DCC to mediate neurite outgrowth.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:  
Grading scheme (The final report must be worth at least 50% of final grade): Laboratory work (50%) + 10 page report essay (50%)
Other project information:
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? One or more of the following
Animal subjects [ ]
Human subjects [ ]
Biohazardous substances [x]
Radioactive materials [ ]
Handling chemicals [ ]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:
Email (first.last [at] mail.mcgill.ca):
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):
Level (U0 / U1 / U2 / U3):
Student signature - I have not applied for another '396' course in this term:
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: