MIMM 397: "Histamine and histamine metabolite measurement using..." (Prof. C. Tsoukas)

INSTRUCTIONS - PROFESSORS: Fill out Sections A & B then submit this form online. (You will receive an email copy of the form. The Office for Undergraduate Research in Science will also post the project online, indicating whether the project is open for students to apply or taken.) DONE
INSTRUCTIONS - STUDENTS: You may receive this form by email, or you may download it after it has been posted. Either way, print this form. Complete and sign Section C on the hardcopy. Ask your supervisor to sign Section D. Take it to the department corresponding to the course number in Section A (this may or may not be your own department). Do not register for a '396' course on Minerva until you receive departmental permission.
INSTRUCTIONS - DEPARTMENTS: After the unit chair/director/designate approves (or not) this project, notify student. If approved, please give student permission to register on Minerva, and fax this form (with signatures) to the Office for Undergraduate Research in Science at 514-398-8102.
QUESTIONS OR FEEDBACK? Contact Victor Chisholm by email, or phone 514-398-5964.
Name: Prof. Chris Tsoukas
Email: chris.tsoukas [at] muhc.mcgill.ca
Phone: 514-934-1934 #48035
Supervisor's department: Microbiology and Immunology
Supervisor's department (if none of the above) Clinical Immunology and Allergy
Course number: MIMM397 (Immunology)
Term: Fall 2009-2010
Project start date: September 1, 2009
Project end date: December 3, 2009
Project title: Histamine and histamine metabolite measurement using mass spectrometry to aid in the diagnosis of IgE-mediated allergy, and anaphylactoid reactions.
Project description: The diagnostic tools we currently have available to establish the presence of allergies to foods and medications are limited and place patients at risk of anaphylaxis. The proposed project aims to validate the use of mass spectrometry for measurements of changes in histamine and N-methylhistamine in the setting of challenges used to document presence or absence of allergic symptoms. Mass spedctrometry is expected to be as sensitive as currently available commercial assays, while being more affordable. The cost of commercial assays is prohibitive for their routine clinical use.

Once validated, our proposed method will permit of the mass spectrometry histamine and N-methyhistamine measurement in in vitro assays which may allow us to diagnose allergies to foods and drugs without placing the patient at risk for adverse events.
Prerequisite: 1 term completed at McGill + CGPA of 3.0 or higher; or permission of instructor.
Other prerequisite, if applicable:
Grading scheme (The final report must be worth at least 50% of final grade): Final grade shall be based on laboratory performance as evaluated by the research supervisor (50%) and the final written research report (minimum 10 pages) graded by the supervisor and the course coordinator or the coordinator's delegate (50%).
Other project information:
Project status - This project is: Taken. The professor has no more '396' projects this term.
How students can apply: N/A; this project is filled.
If other, please specify:  
Ethics, safety, and training
Which of the following, if any, is involved? One or more of the following
Animal subjects [ ]
Human subjects [x]
Biohazardous substances [ ]
Radioactive materials [ ]
Handling chemicals [x]
Using lasers [ ]
Supervisors are responsible for the ethics and safety compliance of undergraduate students.
Do not complete this section unless/until the student is identified.
McGill ID:
Email (first.last [at] mail.mcgill.ca):
Program (E.g., B.Sc. Maj. Chem. Min. Biol.):
Level (U0 / U1 / U2 / U3):
Student signature - I have not applied for another '396' course in this term:  
Do not complete this section unless/until the student is identified.
Supervisor: I give my permission for the student identified in section C to register for this project under my supervision.
Supervisor's signature:  
Unit chair/director/designate: I certify that this project conforms to departmental requirements for 396 courses.
Unit chair/director/designate's name:  
Unit chair/director/designate's signature: