Master/Ph.D. students or junior postdoctoral fellows
are encouraged to apply to the Rouiller Laboratory in the Department of Anatomy and Cell Biology at McGill University, Montréal, Québec, Canada. The laboratory combines biochemistry with the powerful imaging techniques of cryo-electron microscopy and cryo-electron tomography to investigate large, dynamic molecular machines and their function in complex cellular events. In particular, the research uses a structure/function approach to study the cellular mechanisms that enable transport of proteins across membranes and between different cellular compartments. Specific projects include the investigation of toxin and virus entry into mammalian cells and the role of AAA ATPases in membrane crossing.
In addition to being well-equipped for protein expression, purification and various biochemical and light microscopy assays, the laboratory has unrestricted access to the state-of-art Facility for Electron Microscopy Research (FEMR). The FEMR houses two TEMs dedicated to life sciences; the FEI Tecnai 12 (120 kV) TEM and the FEI Tecnai G2 F20 200 kV cryo-FE-S/TEM equipped with a Gatan Ultrascan CCD camera and EDAX EDS, and in the Fall 2008, will receive the Titan Krios 300 kV cryo-FE-S/TEM equipped with a Gatan Ultrascan CCD camera and GIF system. In addition, the laboratory has access to a supercomputer through the consortium CLUMEQ.
Applicants should be highly motivated and have a strong background in structural biology . Previous experience in electron microscopy, image processing, or protein expression and purification are definite assets.
Interested candidates should send a CV that includes areas of expertise and research interests, publications list, and contact information for three references to Dr. Isabelle Rouiller's isabelle.rouiller [at] mcgill.ca (email) .
Announcement: A new scholarship program has been introduced (Budget 2008): the Canada Graduate Scholarships Program. The program aims as attracting the best students to Canadian research laboratories. The Government will support Canada’s top graduate students through the Canada Graduate Scholarships Program. This new prestigious Canada Graduate Scholarship award, when fully in place will support 500 top Canadian and international doctoral students a year. The new scholarships will be dedicated to the memory of Georges Philias Vanier, decorated soldier, distinguished ambassador, and Governor General of Canada. The new award is designed to attract the world’s best doctoral students to Canadian universities, and will be worth $50,000 per year for up to three years. Students with an excellent academic bakground, interested in learning the cutting edge cryo-EM technology are encouraged to contact Dr. Isabelle Rouiller by isabelle.rouiller [at] mcgill.ca (email) to submit an application to this program.