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UID:20261001T055614EDT-8199p6ViEI@132.216.98.100
DTSTAMP:20261001T095614Z
DESCRIPTION:'Unconventional NMDA Receptor Signalling in Neocortical Plastic
 ity'\n\nJesper Sjostrom\, McGill University\n	Tuesday January 28\, 12-1pm\n
 	Montreal Neurological Institute\, deGrandpre Communications Centre\n	\n	Abst
 ract: In the classical view\, postsynaptic NMDA receptors (NMDARs) trigger
  Hebbian plasticity via calcium influx. However\, unconventional presynapt
 ic NMDARs (preNMDARs) which regulate both long-term and short-term plastic
 ity at several synapse types have also been found. A lack of sufficiently 
 specific experimental manipulations and a poor understanding of how preNMD
 ARs signal have contributed to long-standing controversy surrounding these
  receptors. Our recent work indicates that\, whereas ionotropic preNMDARs 
 signaling controls evoked release\, spontaneous release is regulated by me
 tabotropic NMDAR signaling. Elucidating unconventional NMDAR signaling mod
 es — both presynaptically and metabotropically — is in other words key to 
 a full understanding of NMDAR function in health as well as disease.\n
DTSTART:20200128T170000Z
DTEND:20200128T180000Z
LOCATION:deGrandpre Communications Centre\, Montreal Neurological Institute
 \, CA\, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:QLS Seminar - Jesper Sjostrom
URL:https://www.mcgill.ca/qls/channels/event/qls-seminar-jesper-sjostrom-30
 3832
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