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UID:20260921T100632EDT-7519atMWaz@132.216.98.100
DTSTAMP:20260921T140632Z
DESCRIPTION:Brain imaging genetics in the UK Biobank\n\nJonathan Marchini\n
 \nStatistics\, University of Oxford\n\n \n\nAbstract: Brain structure\, fu
 nction and connectivity are known to vary between individuals in the human
  population. Changes in these features have been identified in many neurol
 ogical and psychiatric disorders such as Alzheimer's disease\, Parkinson's
  disease\, schizophrenia\, major depression\, autism\, bipolar disorder as
  well as drug addiction. Understanding the genetic basis of these brain tr
 aits will have high relevance to neurological\, psychiatric\, degenerative
  and developmental disorders.\n\n \n\nIn 2017 the UK Biobank released high
  quality brain imaging data on 10\,000 subjects. A fully automated process
 ing pipeline has been developed for UK Biobank that produces both processe
 d images as well as image-derived phenotypes (IDPs)\; this generates thous
 ands of distinct individual measures of brain structure and function. Exam
 ple IDPs include the volume of specific brain structures\, the strength of
  connectivity between pairs of brain regions and the dispersion of fibers 
 in a given white-matter tract.\n\nUK Biobank has also collected genome-wid
 e genetic data on every participant using a purpose-designed genotyping ar
 ray. A custom quality control\, phasing and imputation pipeline was develo
 ped to address the challenges specific to the experimental design\, scale\
 , and diversity of the UK Biobank dataset. The genetic data was released t
 o researchers with approved access in July 2017 and consists of ~96 millio
 n genetic variants in ~500\,000 study participants.\n\nThe talk will descr
 ibe the joint analysis of the genetic and brain imaging datasets available
  from UK Biobank. This will include a decription of some of the novel meth
 ods we have developed to cope with the scale of the genetic and brain imag
 ing data\, as well as a description of the main findings of the study so f
 ar.\n
DTSTART:20180322T160000Z
DTEND:20180322T170000Z
LOCATION:521\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3
 655 promenade Sir William Osler
SUMMARY:QLS Featured Seminar Series - Dr. Jonathan Marchini
URL:https://www.mcgill.ca/qls/channels/event/qls-featured-seminar-series-dr
 -jonathan-marchini-285583
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