BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260403T113323EDT-0726MVTwKo@132.216.98.100 DTSTAMP:20260403T153323Z DESCRIPTION:This annual lecture honours Dr. Albert Aguayo\, OC\, FRCP\, Pro fessor Emeritus founder and former Director of the Centre for the Research in Neuroscience at McGill University.\n\n\nRegister Now\n\nTo watch onlin e\, click here\n\n\nDo You Remember? Let Me Explain You How.\n\nTalk Abstr act: A general wisdom is that only selected aspects of our experiences are remembered. Extensive work over the past decades has shown that sleep pla ys a critical role in the consolidation process of memory. We identified a brain pattern\, known as sharp wave-ripple (SPW-R)\, that supports the “r eplay” of waking experience in compressed snippets (~100 ms) in the hippoc ampal-neocortical circuits. SPW-Rs evolved in evolution to support body fu nctions\, such as regulating glucose levels and hormone release\, and we e xapted to serve cognitive functions\, parallel with the development of the neocortex. SPW-Rs are present in the resting and waking brain\, and these compressed information packages repeat fragments of learned information 2 000 to 4000 times each night during non-REM sleep. However\, brain mechani sms that select experiences for lasting memory are not known. To address t he selection (or “credit assignment”) problem\, we combined large-scale ne ural recordings with a novel application of dimensionality-reduction techn iques in rodents. When the brain state changed from theta oscillations dur ing maze exploration to SPW-Rs during reward consumption\, the spike conte nt of SPW-Rs decoded the trial in which they occurred. In turn\, during po st-experience sleep\, SPW-Rs continued to replay those trial contents that were reactivated most frequently during waking SPW-Rs. These findings dem onstrate that the replay content of awake SPW-Rs provides a tagging mechan ism to select critical aspects of experience that are consolidated and pre served for future use during sleep. In related experiments\, we aborted or prolonged SPW-Rs by closed-loop optogenetic methods and demonstrated impa ired and enhanced memory of the previous experience\, respectively. Thus\, SPW-Rs provide a hippocampal mechanism for prioritizing and tagging aspec ts of experience and consolidating them during post-learning sleep.\n\nGyö rgy Buzsáki\n\n\n\nGyörgy Buzsáki is Biggs Professor of Neuroscience at Ne w York University. His main focus is “neural syntax”\, i.e.\, how the nume rous brain rhythms organize segmentation of neural information to support cognitive functions. He is among the top 0.1% of most-cited neuroscientist s and an elected member of the National Academy of Sciences USA\, Academia e Europaeae\, and the Hungarian Academy of Sciences. He sits on the editor ial boards of several leading neuroscience journals\, including Science an d Neuron\, honoris causa at Université Aix-Marseille\, France and Universi ty of Kaposvar\, Hungary and University of Pécs\, Hungary. He is a co-reci pient of the 2011 Brain Prize and the recipient of the 2020 Ralph Gerard A ward (SFN). (Books: G. Buzsáki\, Rhythms of the Brain\, Oxford University Press\, 2006\; The Brain from Inside Out\, OUP\, 2019)\n\n\nThis event is generously supported by the Rose Wiselberg Foundation.\n\n \n DTSTART:20260427T200000Z DTEND:20260427T210000Z LOCATION:Jeanne-Timmins Amphitheatre\, The Neuro SUMMARY:Albert Aguayo Lecture: Do You Remember? Let Me Explain You How. URL:https://www.mcgill.ca/plasticsurgery/channels/event/albert-aguayo-lectu re-do-you-remember-let-me-explain-you-how-367445 END:VEVENT END:VCALENDAR