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UID:20260920T194913EDT-0568kvm6vF@132.216.98.100
DTSTAMP:20260920T234913Z
DESCRIPTION:Core splicing factors are essential for mRNA maturation and alt
 ernative splicing. Hence\, they are essential for generating the diversity
  of mRNA and proteins found in cells and for coordinated regulation of the
  cellular processes essential for morphogenesis. Curiously\, heterozygous 
 mutations in a subset of core-splicing factors result tissue-specific malf
 ormations in newborn head and face\, and limbs. The cellular mechanism tha
 t links the tissue-specific defects found in spliceosomopathies\, if any\,
  remains a mystery. In this talk I will present work by our group aimed at
  identifying the dysregulated cellular processes that are responsible for 
 craniofacial and limb malformations in mutant mouse models with mutation o
 f core-splicing factors.\n\nThis seminar will take place in -person and on
 line (details in the  attached poster below) All are welcome!\n
DTSTART:20231208T160000Z
DTEND:20231208T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Dr. Loydie A. Jerome- Majewska 'Are craniofacia
 l spliceosomopathies due to depletion of neural stem cells?'  
URL:https://www.mcgill.ca/physiology/channels/event/physiology-seminar-dr-l
 oydie-jerome-majewska-are-craniofacial-spliceosomopathies-due-depletion-35
 3030
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