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UID:20260728T031610EDT-01458V1Vtl@132.216.98.100
DTSTAMP:20260728T071610Z
DESCRIPTION:Human pluripotent stem cells (hPSCs) have a number of attractiv
 e properties for myocardial infarct (MI) repair\, including a tremendous c
 apacity for expansion in the undifferentiated state and the ability to dif
 ferentiate into phenotypically unambiguous cardiomyocytes. Our group has c
 ontributed reliable methods for the scaled generation of hPSC-derived card
 iomyocytes (hPSC-CMs)\, and we have shown that hPSC-CMs can partially remu
 scularize the infarct scar and mediate beneficial effects on contractile f
 unction in multiple preclinical MI models. In recent work in the translati
 onally relevant porcine MI model\, we have shown that hPSC-CM transplantat
 ion results in large (cubic centimeters-scale) human myocardial implants t
 hat show progressive maturation over time\, form vascular networks with th
 e host\, and evoke minimal cellular rejection. That said\, a number of imp
 ortant barriers to translation remain\, including concerns about the immat
 ure and heterogeneous phenotype of hPSC-derived cardiomyocytes\, incomplet
 e host-graft integration following transplantation\, and the occurrence of
  frequent graft-related tachyarrhythmias. In this presentation\, I will su
 mmarize our recent efforts to overcome these hurdles via the delivery of m
 ore mature cardiomyocyte populations\, and I will describe an efficient\, 
 economic protocol for the large-scale manufacturing of mature ventricular 
 hPSC-CMs. In transplantation studies comparing in vitro matured hPSC-CMs t
 o conventional immature populations\, we have found that both exhibit comp
 arable levels of engraftment in injured hearts\, but the matured cells for
 m graft tissue with profoundly enhanced cardiac structure and alignment. M
 ost importantly\, hearts with mature hPSC-CM grafts exhibit better functio
 nal outcomes\, including greatly improved electromechanical integration\, 
 reduced pro-arrhythmic behavior\, and a greater increment of contractile r
 ecovery.\n\nthis seminar is taking place in person and online details in t
 he poster below. All are welcome!\n
DTSTART:20230922T150000Z
DTEND:20230922T160000Z
LOCATION:1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 
 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: Dr. Michael Laflamme:' Heart regeneration with 
 human pluripotent stem cells'
URL:https://www.mcgill.ca/physiology/channels/event/physiology-seminar-dr-m
 ichael-laflamme-heart-regeneration-human-pluripotent-stem-cells-351005
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