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UID:20261027T084407EDT-6732Ek4nU8@132.216.98.100
DTSTAMP:20261027T124407Z
DESCRIPTION:Sensory cortices apply a top-down modulation of innate motor be
 haviours throughout corticofugal projections that target phylogenetically-
 old brainstem nuclei. However\, it remains unknown whether the functional 
 properties of these projections match the properties of the innate behavio
 urs they modulate. Here\, I will present evidence that visual cortical neu
 rons projecting to the brainstem optic-tract and dorsal-terminal nuclei (N
 OT-DTN) transmit motion signals relevant to the optokinetic reflex (OKR)\,
  a brainstem-mediated innate eye movement that is paramount for vision. Re
 markably\, enriched in specific visual areas these neurons prefer temporo-
 nasal visual motion\, sharing the direction bias of downstream NOT-DTN neu
 rons. Furthermore\, the activity of temporo-nasally biasing cortical neuro
 ns is selectively enhanced when OKR is potentiated. These functional speci
 ficities allow efficiently integrating cortical input in NOT-DTN neurons t
 o support OKR potentiation. Lastly\, I will pinpoint the synaptic target o
 f the corticofugal projection by showing that the visual cortex innervates
  only one subpopulation of NOT-DTN neurons\, which project specifically to
  the inferior olive (IO) in the brainstem. This IO projecting NOT-DTN popu
 lation also prefers the temporo-nasal motion\, and is critical for the cor
 tical contribution to the OKR. Overall\, our results provide compelling ev
 idence that a direction-selective descending pathway connects the visual c
 ortex and brainstem\, which conducts functionally relevant information and
  specializes in adaptively modulating the OKR.\n\nThis seminar will take p
 lace in-person and online (details in the attached poster below)\n\n \n
DTSTART:20230505T150000Z
DTEND:20230505T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar: A Direction-selective Top-down Pathway Adaptive
 ly Modulates Innate Behaviors 
URL:https://www.mcgill.ca/physiology/channels/event/physiology-seminar-dire
 ction-selective-top-down-pathway-adaptively-modulates-innate-behaviors-347
 896
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