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UID:20260526T232249EDT-8461oVDliA@132.216.98.100
DTSTAMP:20260527T032249Z
DESCRIPTION:The adult mammalian brain retains a remarkable capacity to prod
 uce new neurons throughout life. Adult neurogenesis is most prominent in t
 he mammalian forebrain where neural stem cells (NSCs) located in a special
 ized micro-environment need to integrate multiple signals to remain quiesc
 ent or be activated to generate neuronal precursors and glia. The neuronal
  precursors migrate long distances to reach the olfactory bulb (OB) where 
 they integrate into adult neuronal networks and play an important role in 
 the odor processing.\n\nIn the first part of the talk\, I will discuss som
 e of our unpublished data aiming to determine how adult NSCs integrate and
  decode various microenvironmental signals that drive them to divide or to
  remain poised for future needs. Of the many intracellular pathways that a
 re at play in somatic stem cells of different organs\, Ca2+ signaling is e
 merging as a key signaling hub on which multiple extracellular cues may im
 pinge to dynamically regulate Ca2+ fluctuations and steady-state intracell
 ular levels\, which in turn regulate somatic stem cell quiescence and acti
 vation. Using 2photon Ca2+ imaging in thin NSC processes ex vivo in brain 
 slices followed by iterative immunostaining to identify all niche elements
  that are in contact with imaged cells\, our data suggest that adult NSCs 
 integrate inputs from multiple niche elements at the level of their proces
 ses by dynamically regulated spatio-temporal pattern of Ca2+ fluctuations.
 \n\nIn the second part of the talk\, I will discuss the role of substantia
  innominata (SI)\, a small nucleus in the basal forebrain in the odor proc
 essing. Using mini-endoscopic Ca2+ imaging in freely behaving mice combine
 d with measurements of active sniffing\, our data demonstrate that neurona
 l activity in SI is specifically tuned to active sniffing and that these n
 eurons project back into OB to synapse with specific type of interneurons 
 and regulate odor processing.\n\nThis seminar will take place both in-pers
 on and online. Details in attached poster\n
DTSTART:20221125T160000Z
DTEND:20221125T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Physiology Seminar 'Integration and decoding of micro-environmental
  signals: from neural stem cells to mature neurons' 
URL:https://www.mcgill.ca/physiology/channels/event/physiology-seminar-inte
 gration-and-decoding-micro-environmental-signals-neural-stem-cells-mature-
 343612
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