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UID:20260728T034434EDT-5853EDXKXo@132.216.98.100
DTSTAMP:20260728T074434Z
DESCRIPTION:\n	A major unanswered question in biology is how mechanical forc
 es are generated\, detected and transduced by cells to impact biochemical 
 and genetic programs. Our work is aimed at uncovering the mechanical princ
 iples at play in cells and tissues using novel molecular\, imaging and bio
 engineering tools. Here we present insights gleaned from non-invasive appr
 oaches to measure and manipulate mechanical signals in native cellular con
 ditions. We find that the mechanically-activated ion channel Piezo1 transd
 uces cell-generated traction forces to regulate a variety of physiological
  processes. We show that actomyosin-based cellular traction forces generat
 e spatially-restricted Piezo1 Ca2+ flickers in the absence of externally-a
 pplied mechanical forces. Although Piezo1 channels diffuse readily in the 
 plasma membrane and are widely distributed across the cell\, their Ca2+ fl
 icker activity is enriched in regions proximal to force-producing adhesion
 s. We propose that Piezo1 Ca2+ flickers allow spatial segregation of mecha
 notransduction events\, and that mobility allows channel molecules to effi
 ciently respond to local mechanical stimuli.\n\nThis seminar will be avail
 able both in-person and online\, details in attached poster.\n
DTSTART:20220506T150000Z
DTEND:20220506T160000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar - Watching Cellular Mechanotransduction: Piezo1 Activation 
 by Cellular Traction Forces
URL:https://www.mcgill.ca/physiology/channels/event/seminar-watching-cellul
 ar-mechanotransduction-piezo1-activation-cellular-traction-forces-338480
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