Dr. Sabah Noori Abdul Hussain is a James McGill Professor in the Department of Medicine ,( Critical Care and Respiratory Divisions appointed since July 1st, 2005); Medical Director at Pulmonary Function Laboratories since july 1999 and the Research Director at Meakins-Christie Labs of the MUHC since july 1991. Dr. Hussain joined the Department of Pathology as an associate member in 2017.
Dr. Hussain is currently involved in three main areas of research. First, his laboratory is currently investigating molecular signaling pathways and mechanisms of action of angiogenesis factors in general and angiopoietins and Tie-2 receptors in particular. Current project include identification of transcription factor networks downstream from Tie-2 receptors both in endothelial cells and in cultured skeletal muscle satellite cells. In addition, his laboratory is exploring the biological functions of both angiopoietin-1 and angiopoietin-2 in regulating cytokine cascade and tissue injury in various models of inflammation including severe sepsis and acute lung injury. To achieve the objective in this area of research his laboratory has developed transgenic animal models to over-express angiopoietins selectively in the vasculature. His second area of research is the biological roles of angiopoietins in skeletal muscle regeneration with particular emphasis on ventilatory muscle function. In this regard, we are investigating the effectiveness of gene therapy in which angiopoietins are delivered in vivo in various models of skeletal muscle injury and regeneration including cardiotoxin necrosis model and mdx model of Duchenne Muscular Dystrophy. His third area of research interest is molecular mechanisms involved in skeletal muscle atrophy in general and regulation of autophagy and proteosomal pathways in particular. Current research project include assessing the contribution of autophagic pathway to skeletal muscle protein degradation in human diaphragm during mechanical ventilation.