Macdonald Campus, McGill University

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11:30 am

de'Broski Herbert, Univ Pennsylvania Vet School
How Can IL-33 Serve Critical Roles in Both Resistance and Susceptibility to Helminths?

Immune control of helminths is achieved via type 2 immune responses involving group 2 innate lymphoid cells (ILC2), with interleukin-33 (IL-33) supporting the expansion and activation of ILC2. We have used a mouse model of Nippostrongylus brasiliensis infection to investigate the effects of selectively deleting the IL-33 gene in intestinal epithelial cells or CD11c+dendritic cells (DCs). Epithelial cell IL-33 promoted clearance of infection by ILC2, but IL-33 from DCs instead impaired worm clearance by enhancing Treg function. IL-33 expression by DCs increased expression of the pore-forming protein perforin-2, which may provide a conduit on the plasma membrane for IL-33 to leave the cell. This provides new insights into the cellular mechanisms controlling extracellular release of IL-33.

Dr Herbert has a BSc in microbiology and a PhD in immunology and he did his PDF at the University of Cape Town, South Africa. Through the study of parasitic helminths and protozoa, his team has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and GI tract.

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