Paul A. Martineau
MDCM, FRCSC, ABOS, SCOSM
American-British-Canadian (ABC) Traveling Fellowship
American Orthopaedic Association
Canadian Orthopaedic Association
Upper Extremity, Hand and Microsurgery Fellowship
Harborview Medical Center and
University of Washington Medical Center
University of Washington, Seattle, Washington, USA
Sport Medicine and Arthroscopic Surgery Fellowship
Cleveland Clinic Foundation, Cleveland, Ohio, USA
Co-director Regenerative Orthopaedics and Innovation Lab
Arthroscopic Surgery of the Knee and of the Upper Extremity
Upper Extremity Surgery
Orthopaedic Sports Medicine
My research program is focused on novel approaches for improving musculoskeletal health and spans from developing diagnostic imaging strategies, surgical innovation and implant design, as well as a focus on osteoimmunology. Our main areas of research are presently:
- Pioneering a user-friendly anterior cruciate ligament (ACL) injury prevention application of particular relevance to female athletes. The application will be a useful screening tool for athletes at risk of injury and could be adopted by medical professionals but also by coaches, parents and athletes themselves with the goal of widespread, accessible, ACL injury prevention.
- Harnessing the body’s own immune response to injury to promote tissue healing. This strategy could be used to promote better repair tissue in patients at high risk of fracture complications or even to prepare patients prior to undergoing surgical interventions that require bone healing.
- Hart A, Sivakumaran T, Burman M, Powell T, Martineau PA. Anatomic Anterior Cruciate Ligament Reconstruction – A Prospective Evaluation using Three-Dimensional Magnetic Resonance Imaging. AJSM, 2018, 46(1): 192-199.
- Pedneault C, Laverdiere C, Boily M, Hart A, Burman M, Martineau PA. Evaluating the Accuracy of Tibial Tunnel Placement After Anatomic Single-Bundle Anterior Cruciate Ligament Reconstruction. AJSM, 2019, 47(13):3187-3194 https://doi.org/10.1177/0363546519873633.
Relevance: ACL reconstruction is one of the most commonly performed surgical procedures. Increasing our understanding of the anatomy and pathoanatomy with novel diagnostic techniques will help guide the development of more anatomic and reproducible reconstruction techniques. We are defining patient specific ACL injury parameters to optimize reconstruction techniques and maximize ACL injury prevention.
Target community: Surgeons treating ACL injuries and patients with ACL injuries.
Impact: Moving away from “one-size fits all” ACL reconstruction towards patient specific ACL treatment.
- Martineau PA. Systems, Methods and Apparatus for Prevention of Injury.
US Patent application, # 16532450, August 05 2019
PCT Filing, PCT/US20.42424, July 16, 2020
Relevance: We are developing a novel, user-friendly, portable, low-cost, accessible ACL injury prevention application.
Target community: Everyone who participates in sports with a particular relevance to female athletes who are eight times more at risk of sustaining an ACL injury then their male counterparts.
Impact: At the end of the project, our ACL injury prevention application will become a useful useful screening tool for athletes at risk of ACL injury and could be adopted by medical professionals but also by coaches, parents and athletes themselves, with the goal of widespread, accessible, ACL injury prevention at the global level.
- Ramirez-GarciaLuna J, Wong TH, Chan D, Al-Saran Y, Awlia A, Abou-Rjeili M, Ouellet S, Akoury E, Lemarie CA, Henderson JE, Martineau PA. Defective Bone Repair in Diclofenac Treated C57Bl6 Mice with and without Lypopolysaccharide Induced Systemic Inflammation. Journal of Cellular Physiology, 2019, 234(3): 3078-3087.
- Ramirez Garcia Luna J, Chan D, Samberg R, Feyerabend T, Rodewald HR, Henderson JE, Martineau PA. Defective Bone Repair in Mast Cell-Deficient Cpa3Cre/+ Mice. PLOS One, 2017, 12(3):e0174396. pubmed/28350850
Relevance: Mast cells have historically been described as villainous mediators of allergic response. Our body of work is defining a valuable role for mast cells as important coordinators and mediators of tissue homeostasis and regeneration. We have become research leaders in the field of osteoimmunology.
Target community: All fractures or patients undergoing procedures requiring bone healing.
Impact: Augmenting bone healing is of paramount importance to the enormous amount of patients at risk of osteoporotic fractures and to the millions of patients undergoing surgeries that require successful osteointegration to be successful