Tackling adherence to treatment on several fronts

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Innovative trial combines digital technology and coaching to improve adherence to treatment among young kidney transplant patients

Learning to become self-sufficient and responsible is part of life’s journey through the teen and young adult years. Mistakes are often made, and lessons are learned. However, for young kidney-graft patients, any mistake or failure in keeping to their strict immunosuppressive therapy can lead to tragic results. In fact, low-adherence to medication remains a major contributor to the high level of organ rejection in this age group.

Audrey Grenier received a kidney transplant when she was 13-years-old and participated in the TAKE-IT clinical trial led by Dr. Bethany Foster (right), pediatric nephrologist at the Montreal Children's Hospital and scientist at the Research Institute of the MUHC.

Transplant specialists and researchers from eight leading pediatric medical centres across Canada and the United States have united to help make a difference. Led by Dr. Bethany Foster, a pediatric nephrologist and scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) and the Montreal Children’s Hospital of the MUHC, the team conducted a clinical trial named TAKE-IT aimed at testing a new intervention to improve adherence to treatment among adolescent kidney transplant recipients. Their results are published today online in The American Journal of Kidney Diseases (AJKD).

“Missing your anti-rejection medicine, even only a few times, can lead to graft failure,” says Dr. Foster, corresponding author of the study, who is also a researcher from the Child Health and Human Development Program at the RI-MUHC and a professor of Medicine at McGill University. “Given the shortage of organs available for transplant, every failure is not only a loss for the patient but also a loss for the transplant community.”

Medication non-adherence is a major problem in the 15 to 30 per cent of children in North America who have a chronic illness, resulting in significant morbidity and mortality. It is also believed to be responsible for millions of dollars in potentially avoidable healthcare costs.

TAKE-IT: Multiplying tactics to help young patients follow treatment
The TAKE-IT intervention used a combination of electronic medication monitoring and meetings with a personal coach every three months to encourage and develop adherence behaviour. The researchers followed 169 adolescent and young adult kidney transplant recipients (aged 11 to 24 years old) for a year. Participants used the SimpleMed electronic pillbox, developed by the medical company Vaica, to monitor their medication-taking. The cohort of patients was divided into two groups. The first group (81 patients) could customize the monitoring system to send them digital nudges like emails or text messages if they did not take their medicine on time. They also received coaching from people who were not part of or did not interact with the clinical team. Members of the second group, known as the control group (88 patients), didn’t receive electronic messaging or adherence coaching.

Results of the trial show that the young kidney transplant recipients who used the digital health medication management and adherence solution in combination with coaching had a 66 per cent higher adherence to the anti-rejection medicine. Better adherence is likely to lead to better graft survival.

Reactions to the intervention program varied. “Some people loved it and didn't want to give the pillbox back, but others hated it and stopped using it for reasons such as the pillbox being unwieldy. Based on this feedback, the device is being re-designed,” Dr. Foster says. “Most teens, however, liked meeting with the coach.”

“These results are exciting because they show that a multidisciplinary approach can really help teens and young adults stick to their treatment plan, which is so important for their continued well-being,” adds study co-author, Dr. Lorraine Bell, who is the director of the MUHC Pediatric Renal Transplant Program and the director of the Pediatric Transition to Adult Care Project at the Montreal Children’s Hospital of the MUHC. “The coaching has a big impact as it does in sports and other activities – the encouragement and personal connection is important, because it’s not easy to be a teen or young adult with a chronic health condition.”

Dr. Bell also emphasizes that remembering to take meds can be difficult when a lot of other things are happening in the lives of these young patients, and points out the benefit of text message and email reminders for a population who grew up using cellphones.

“This is one of the largest clinical trials on adherence to daily medication ever conducted in the kidney transplant population. Identifying an approach that is effective in promoting adherence in patients with chronic conditions is a major advance,” says Dr. Foster. “Better adherence will lead to healthier patients and is likely to save healthcare dollars by preventing serious complications that would need treatment or hospitalization.”

The TAKE-IT trial was launched in 2011. It is currently being followed up by a large-scale, five-year study (called TAKE-IT TOO) in which study investigators will collaborate with Vaica, and with patients, parents and healthcare professionals to design a portable medication monitoring and adherence support system specifically for young people, to adapt the TAKE-IT intervention for use in clinical practice, and to test the new device and intervention in a pilot trial.

About the study
The study A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT) was co-authored by Bethany J. Foster, Ahna L.H. Pai, Nataliya Zelikovsky, Sandra Amaral, Lorraine Bell, Vikas R. Dharnidharka, Diane Hebert, Crystal Holly, Baerbel Knauper, Douglas Matsell, Veronique Phan, Rachel Rogers, Jodi M. Smith, Huaqing Zhao, and Susan L. Furth. DOI: 10.1053/ j.ajkd.2017.12.012

The study was funded by the National Institutes of Health (NIH), National Institutes of Diabetes and Digestive and Kidney Diseases (R01DK092977). Dr Foster, a member of the Research Institute of the McGill University Health Centre, was supported by a Fonds de recherche du Quebec Santé.

About the Research Institute of the MUHC 
The Research Institute of the McGill University Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. The Institute, which is affiliated with the Faculty of Medicine of McGill University, is the research arm of the McGill University Health Centre (MUHC) – an academic health centre located in Montreal, Canada, that has a mandate to focus on complex care within its community. The RI-MUHC supports over 420 researchers and close to 1,200 research trainees devoted to a broad spectrum of fundamental, clinical and health outcomes research at the Glen and the Montreal General Hospital sites of the MUHC. Its research facilities offer a dynamic multidisciplinary environment that fosters collaboration and leverages discovery aimed at improving the health of individual patients across their lifespan. The RI-MUHC is supported in part by the Fonds de recherche du Québec – Santé (FRQS). www.rimuhc.ca

(Photo: SimpleMed electronic pillbox (developed by Vaica) used by participants to monitor their medication-taking during the clinical trial TAKE-IT)

Media contact:
Julie Robert
Communications Coordinator – Research

McGill University Health Centre

514-971-4747 (cell)
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julie.robert [at] muhc.mcgill.ca