Tanja Kuhlmann, MD

Tanja Kuhlmann, MD
Biography: 

Dr. Tanja Kuhlmann studied medicine at the University of Göttingen, Germany where she received her medical degree in 1998. She specialized in neuropathology and worked as medical resident and research fellow in different neuropathological departments in Germany and at McGill, Canada in the research groups of Dr. Jack Antel and Dr. Alan Peterson. In 2008, she became senior consultant and associate professor, Institute of Neuropatholohgy at the University Hospital Münster, Germany and in 2020 part-time adjunct professor, Department of Neurology and Neurosurgery, McGill University. Her key research interests are mechanisms leading to axonal and oligodendroglial pathology in demyelinating diseases. In recent years, she focused her research on iPSC technology and the derivation of human CNS cells from iPSC to study disease mechanisms. She has published several publications in well-known international journals on the topic of MS pathology, especially on oligodendroglial loss and remyelination as well as studies using iPSC-derived oligodendrocytes and neurons to understand disease mechanisms in demyelinating and neurodegenerative diseases.

Selected publications: 
  1. Chanoumidou K, Hernández-Rodríguez B, Windener F, Thomas C, Stehling M , Mozafari S, Ottoboni L, Antel J, Kee-Pyo K, Velychko S, Cui CL, Martino G, Winkler J, Schöler HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T: One step reprogramming of human fibroblasts into oligodendrocytes using SOX10, OLIG2 and NKX6.2. Stem Cell Reports. 2021 doi: 10.1016/j.stemcr.2021.03.001. Online ahead of print.
  2. StarostL, LindnerM, HeroldM, Xu YKT, Drexler HCA, HeßK, EhrlichM, OttoboniL, RuffiniF, StehlingM, RöpkeA, ThomasC, SchölerHR, AntelJ, WinklerJ, Martino G§, Klotz L§, Kuhlmann§: Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis. Acta Neuropathol. 2020. 140(5):715-736 §Shared last authorship
  3. HeßK, StarostL, KieranNW, ThomasC, VincentenMCJ, AntelJ, MartinoG, HuitingaI, Healy L, KuhlmannT: Stage dependent causes for remyelination failure in MS lesions. Acta Neuropathol. 2020 140(3):359-375.
  4. Weider M*, Starost LJ*, Groll K*, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T#, Wegner M#. Nfat/calcineurin signaling promotes oligodendroglial differentiation and myelination by transcription facor network fine tuning. Nat commun 2018 9: 899 doi: 10.1038/s41467-018-03336-3. * equal contribution. # corresponding authors.
  5. Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H. An updated histological classification system for multiple sclerosis lesions. Acta Neuropathol. 2017 133:13-24
  6. Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. PNAS 2017:114: E2243-E2252. doi: 10.1073/pnas.1614412114
  7. Stangel M, Kuhlmann T, Matthews PM, Kilpatrick TJ. Achievements and obstacles of remyelinating therapies in multiple sclerosis. Nat Rev Neurol. 2017 doi: 10.1038/nrneurol.2017.139 [Epub ahead of print].
  8. Preisener A*, Albrecht S*, Cui Q, Hucke S, Ghelman J, Hartmann C, Taketo MM, Antel J, Klotz L, Kuhlmann T. Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. Acta Neuropathol. 2015; 130: 247-61 *Shared first authorship.
  9. Hargus G,*, Ehrlich M,*, Arauzo-BravoMJ, Hallmann AL, Hemmer K, Reinhardt P, Kim KP, Adachi K, Santourlidis S, Ghanjati F, KimJB, Sterneckert J, SchwambornJ, Schöler HR,Kuhlmann T#, Zaehres H#. Neural induction of human iPS cells reveals origin-dependent neural cell identities in vitro and after transplantation into the adult rodent brain. *and # equal contribution. Cell Reports 2014; 8: 1697-703.
  10. Goldschmidt T, Antel J, König F, Brück W*, Kuhlmann T*. The remyelination capacity of the MS brain decreases with disease chronicity. Neurology 2009, 72: 1914-21. * shared authorship
  11. Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Brück W. Maturation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic MS. Brain 2008, 131: 1749 -58
Research areas: 
Neuroimmunological Diseases

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