Sylvia Villeneuve, PhD

Sylvia Villeneuve, PhD
Contact Information
Alternate phone: 
(514) 761-6131 x3960
Email address: 
sylvia.villeneuve [at]
BIC Core Faculty

Dr. Villeneuve received a PhD from the Université de Montréal in 2011, where she was looking at the nature of memory deficits in vascular and non-vascular individuals with mild cognitive impairments. She did a first postdoctoral fellowship at the University of California Berkeley assessing the interplay between beta-amyloid deposition, vascular diseases and cognition in the preclinical phase of Alzheimer’s disease. She did a second postdoctoral fellowship at Northwestern University where she assessed the predictive value of neurovascular insults, such as deterioration of the blood-brain barrier or reduced cerebral vascular reactivity, to detect early changes associated with amyloid pathology. Dr. Villeneuve is an Assistant Professor at McGill since 2015 and a member of the Ordre des Psychologues du Québec since 2009.

Selected publications: 

Villeneuve S*, Rabinovici G*, Cohn-Sheehy B, Madison C, Ayakta N, Ghosh PM, Madison C, La Joie R, Arthur-Bentil SK, Vogel J, Marks S, Lehmann M, Rosen H, Reed B, Olichney J, DeCarli C, Miller BL, Borys E, Grinberg LT, Jin LW, Seeley WW & Jagust W. Existing PIB Thresholds are Too High: Statistical and Pathological Validation. Brain. 2015;7:2020-2033. doi: 10.1093/brain/awv112.

Villeneuve S, Wirth M & La Joie R. Are AD-typical regions the convergence point of multiple pathologies? Front Aging Neurosci. 2015 doi: 10.3389/fnagi.2015.00042

Villeneuve S & Jagust W. Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment. J Prev Alz Dis 2015;2:64-70. 

Villeneuve S, Reed B, Madison C, Wirth M, Kriger S, Marchant N, Mack W, Sanossian N, DeCarli C, Chui H, Weiner M. & Jagust W. Vascular risk and cerebral β-amyloid interact to reduce cortical thickness. Neurology, 2014;83:1-8. 

Wirth M, Haase C, Villeneuve S, Vogel J. & Jagust W. Neuroprotective Pathways: Lifestyle activity, brain pathology and cognition in cognitively normal older adults. Neurobiol Aging. 2014;35:1873-1882.

Villeneuve S, Reed B, Wirth M, Madison C, Haase C. Ayakta N., M. Mack W, Sanossian N., DeCarli C, Chui H, Weiner M. & Jagust W. Cortical thickness mediates the impact of β-amyloid on episodic memory. Neurology. 2014;82:761-767.

Reed B, Villeneuve S, Mack W, DeCarli C, Chui H, Jagust H, Serum Lipids and Cerebral Amyloidosis in Persons with Elevated Vascular Risk. JAMA Neurology. 2014;71:195-200.

Villeneuve S, Brisson D. Marchant N & Gaudet D. The role of Apolipoprotein E in personalized medicine. Front Aging Neurosci. 2014 doi: 10.3389/fnagi.2014.00154.

Wirth M, Villeneuve S, La Joie R, Marks S. & Jagust W. Gene-Environment interactions: Lifetime cognitive activity, APOE genotype, and beta-amyloid burden. 2014 J Neurosci. 2014;34:8612-8617.

Wirth M, Villeneuve S, Madison C, Oh H, Rabinovici G. & Jagust W. Associations between Alzheimer's disease biomarkers, neurodegeneration, and cognition in normal older people. JAMA Neurology. 2013;70:1512-1519.

Oh H, Madison C, Villeneuve S, Markley C. & Jagust W. Association of gray matter atrophy with age, β-amyloid, and cognition in aging. Cerebral Cortex, 2013, Epub ahead of print. PMID: 23389995

Chao LL, DeCarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack W, Chui HC & Weiner MW. Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLOSone. 2013, 8: e65175. 

Villeneuve S. & Belleville S. The nature of memory failure in mild cognitive impairment: examining association with neurobiological markers and effect of progression, Neurobiol Aging. 2012; 33:1967-1978.

Villeneuve S, Massoud F, Bocti C, Gauthier S. & Belleville S. The nature of episodic memory deficits in MCI with and without vascular burden, Neuropsychologia. 2011; 49:3027-3035. 

Villeneuve S, Belleville S, Massoud F, Bocti C. & Gauthier S. The impact of vascular risk factors and diseases on cognition in persons with mild cognitive impairment, Dement Geriatr Cogn Disord. 2009; 27:375-381. 

Research areas: 
Neuroimaging and Neuroinformatics

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