Simon Ducharme, MD, MSc, FRCPC

 Contact Information

Email: simon.ducharme [at] mcgill.ca (Simon Ducharme)
Tel.: 514-398-1911 Ext: #1
Website: Ducharme
Recent Publications: PubMed
Academic Affiliations: Psychiatry, Neurology and Neurosurgery 
Clinical Interests: Neuropsychiatry, Frontotemporal dementia, Early-onset dementia, Neuropsychiatric aspects of epilepsy and Psychogenic non-epileptic seizures
Research Group: Neuroimaging and Neuroinformatics, Epilepsy


Dr. Simon Ducharme has a medical degree from the Université de Montréal and a Masters from McGill University. He completed his residency in Psychiatry at McGill in 2012, and a fellowship in Behavioral Neurology & Neuropsychiatry at Harvard University in 2014. He has a board certification in Behavioral Neurology & Neuropsychiatry from the United Council for Neurological Subspecialties. He currently works as a Neuropsychiatrist at the Montreal Neurological Institute and a C-L psychiatrist at the MUHC. His clinical interests are frontotemporal dementia and the neuropsychiatric aspects of epilepsy. Dr. Ducharme has received over 35 awards of academic or research excellence, including the 2013 Career Development Award from the American Neuropsychiatric Association. He currently holds an FRQS Junior 1 Clinician-Scientist award. His research uses advanced structural brain imaging techniques to study the longitudinal changes in brain development from childhood to old age, and how it impacts behavior across health and psychopathology. His current projects aim to develop novel neuroimaging diagnostic and prognostic biomarkers for frontotemporal dementia. He is the Montréal site PI of the Genetic Frontotemporal Dementia Initiative study and an FTD team member of the Canadian Consortium on Neurodegeneration in Aging. He is the co-chair of the American Neuropsychiatric Association committee on research and also an associate member of the McGill Centre for Studies in Aging. Dr. Ducharme is in charge of several clinical trials for Alzheimer’s disease and related dementia at the MNI. He is the current research director of the McGill University Health Centre Mental Health Mission.

Selected Publications

Dadar, M., Maranzano, J., Ducharme, S., Carmichael, O. T., Decarli, C., Collins, D. L., & Alzheimer's Disease Neuroimaging Initiative. (2018). Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging. Human Brain Mapping, 39(3), 1093-1107. 10.1002/hbm.23894 Link to item

Victoroff, J., Lin, F. V., Coburn, K. L., Shillcutt, S. D., Voon, V., & Ducharme, S. (2018). Noncognitive behavioral changes associated with alzheimer's disease: Implications of neuroimaging findings. The Journal of Neuropsychiatry and Clinical Neurosciences, 30(1), 14-21. 10.1176/appi.neuropsych.16080155 Link to item

Adelsky, S. J., Ducharme, S., Wilner, E. K., Yudkoff, B., & Lejeune, S. (2017). Heads up: The presentation of schizoaffective disorder in an elite college soccer player with prior concussion. Harvard Review of Psychiatry, 25(6), 302-310. 10.1097/HRP.0000000000000147 Link to item

Albaugh, M. D., Ducharme, S., Karama, S., Watts, R., Lewis, J. D., Orr, C., . . . Brain Development Cooperative Group. (2017). Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths. Development and Psychopathology, 29(3), 751-758. 10.1017/S0954579416000444 Link to item

Albaugh, M. D., Nguyen, T. V., Ducharme, S., Collins, D. L., Botteron, K. N., D'Alberto, N., . . . Brain Development Cooperative Group. (2017). Age-related volumetric change of limbic structures and subclinical anxious/depressed symptomatology in typically developing children and adolescents. Biological Psychology, 124, 133-140. S0301-0511(17)30029-7 Link to item

Ducharme, S., Bajestan, S., Dickerson, B. C., & Voon, V. (2017). Psychiatric presentations of C9orf72 mutation: What are the diagnostic implications for clinicians? The Journal of Neuropsychiatry and Clinical Neurosciences, 29(3), 195-205. 10.1176/appi.neuropsych.16090168 Link to item

Ducharme, S., Price, B. H., & Dickerson, B. C. (2017). Apathy: A neurocircuitry model based on frontotemporal dementia. Journal of Neurology, Neurosurgery, and Psychiatry, jnnp-2017-316277 Link to item

Jette Pomerleau, V., Dubeau, F., & Ducharme, S. (2017). Clozapine safety and efficacy for interictal psychotic disorder in pharmacoresistant epilepsy. Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 30(2), 73-76. 10.1097/WNN.0000000000000127 Link to item

Nguyen, T. V., Ducharme, S., & Karama, S. (2017). Effects of sex steroids in the human brain. Molecular Neurobiology, 54(9), 7507-7519. 10.1007/s12035-016-0198-3 Link to item

Nguyen, T. V., Lew, J., Albaugh, M. D., Botteron, K. N., Hudziak, J. J., Fonov, V. S., . . . McCracken, J. T. (2017). Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function. Psychoneuroendocrinology, 76, 206-217. S0306-4530(16)30999-4 Link to item

Nguyen, T. V., Wu, M., Lew, J., Albaugh, M. D., Botteron, K. N., Hudziak, J. J., . . . McCracken, J. T. (2017). Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development. Psychoneuroendocrinology, 86, 110-121. S0306-4530(17)30549-8 Link to item

Ducharme, S., Albaugh, M. D., Nguyen, T. V., Hudziak, J. J., Mateos-Perez, J. M., Labbe, A., . . . Brain Development Cooperative Group. (2016). Trajectories of cortical thickness maturation in normal brain development--the importance of quality control procedures. Neuroimage, 125, 267-279. S1053-8119(15)00904-0 Link to item

Nguyen, T. V., Gower, P., Albaugh, M. D., Botteron, K. N., Hudziak, J. J., Fonov, V. S., . . . McCracken, J. T. (2016). The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks. Psychoneuroendocrinology, 70, 122-133. 10.1016/j.psyneuen.2016.05.003 Link to item

Nguyen, T. V., McCracken, J. T., Albaugh, M. D., Botteron, K. N., Hudziak, J. J., & Ducharme, S. (2016). Erratum to "A testosterone-related structural brain phenotype predicts aggressive behavior from childhood to adulthood" [psychoneuroendocrinology 63 (2016) 109-118. Psychoneuroendocrinology, 72, 219. S0306-4530(16)30439-5 Link to item

Nguyen, T. V., McCracken, J. T., Albaugh, M. D., Botteron, K. N., Hudziak, J. J., & Ducharme, S. (2016). A testosterone-related structural brain phenotype predicts aggressive behavior from childhood to adulthood. Psychoneuroendocrinology, 63, 109-118. 10.1016/j.psyneuen.2015.09.021 Link to item

Ducharme, S., Albaugh, M. D., Nguyen, T. V., Hudziak, J. J., Mateos-Perez, J. M., Labbe, A., . . . Brain Development Cooperative Group. (2015). Trajectories of cortical surface area and cortical volume maturation in normal brain development. Data in Brief, 5, 929-938. 10.1016/j.dib.2015.10.044 Link to item

Ducharme, S., & Dickerson, B. C. (2015). The neuropsychiatric examination of the young-onset dementias. The Psychiatric Clinics of North America, 38(2), 249-264. 10.1016/j.psc.2015.01.002 Link to item

Ducharme, S., Dickerson, B. C., Larvie, M., & Price, B. H. (2015). Differentiating frontotemporal dementia from catatonia: A complex neuropsychiatric challenge. The Journal of Neuropsychiatry and Clinical Neurosciences, 27(2), e174-6. 10.1176/appi.neuropsych.14070157 Link to item

Ducharme, S., Dickerson, B. C., & Price, B. H. (2015). Improvement in athletic performance as an early symptom of behavioral variant frontotemporal dementia. The Journal of Neuropsychiatry and Clinical Neurosciences, 27(2), e163-4. 10.1176/appi.neuropsych.14060136 Link to item

Ducharme, S., Murray, E. D., Seiner, S. J., Tayeb, H., Legesse, B., & Price, B. H. (2015). Retrospective analysis of the short-term safety of ECT in patients with neurological comorbidities: A guide for pre-ECT neurological evaluations. The Journal of Neuropsychiatry and Clinical Neurosciences, 27(4), 311-321. 10.1176/appi.neuropsych.14080195 Link to item

Ducharme, S., Price, B. H., Larvie, M., Dougherty, D. D., & Dickerson, B. C. (2015). Clinical approach to the differential diagnosis between behavioral variant frontotemporal dementia and primary psychiatric disorders. The American Journal of Psychiatry, 172(9), 827-837. 10.1176/appi.ajp.2015.14101248 Link to item

Karama S, Ducharme S, Corley J, et al. Cigarette smoking and thinning of the brain's cortex. Mol Psychiatry. 2015;20(6):778-85. Link to item

Ameis, S. H., Ducharme, S., Albaugh, M. D., Hudziak, J. J., Botteron, K. N., Lepage, C., . . . Karama, S. (2014). Cortical thickness, cortico-amygdalar networks, and externalizing behaviors in healthy children. Biological Psychiatry, 75(1), 65-72. 10.1016/j.biopsych.2013.06.008 Link to item

Ducharme, S., Albaugh, M. D., Hudziak, J. J., Botteron, K. N., Nguyen, T. V., Truong, C., . . . Brain Development Cooperative Group. (2014). Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults. Cerebral Cortex (New York, N.Y.: 1991), 24(11), 2941-2950. 10.1093/cercor/bht151 Link to item

Hudziak, J. J., Albaugh, M. D., Ducharme, S., Karama, S., Spottswood, M., Crehan, E., . . . Brain Development Cooperative Group. (2014). Cortical thickness maturation and duration of music training: Health-promoting activities shape brain development. Journal of the American Academy of Child and Adolescent Psychiatry, 53(11), 1153-61, 1161.e1-2. 10.1016/j.jaac.2014.06.015 Link to item

Lin, F., Lo, R. Y., Cole, D., Ducharme, S., Chen, D. G., Mapstone, M., . . . Alzheimer's Disease Neuroimaging Initiative. (2014). Longitudinal effects of metabolic syndrome on alzheimer and vascular related brain pathology. Dementia and Geriatric Cognitive Disorders Extra, 4(2), 184-194. 10.1159/000363285 Link to item

Albaugh, M. D., Ducharme, S., Collins, D. L., Botteron, K. N., Althoff, R. R., Evans, A. C., . . . Brain Development Cooperative Group. (2013). Evidence for a cerebral cortical thickness network anti-correlated with amygdalar volume in healthy youths: Implications for the neural substrates of emotion regulation. Neuroimage, 71, 42-49. 10.1016/j.neuroimage.2012.12.071 Link to item

Ducharme, S., Guiot, M. C., Nikelski, J., & Chertkow, H. (2013). Does a positive pittsburgh compound B scan in a patient with dementia equal alzheimer disease? JAMA Neurology, 70(7), 912-914. 10.1001/jamaneurol.2013.420 Link to item

Nguyen, T. V., McCracken, J., Ducharme, S., Botteron, K. N., Mahabir, M., Johnson, W., . . . Brain Development Cooperative Group. (2013). Testosterone-related cortical maturation across childhood and adolescence. Cerebral Cortex (New York, N.Y.: 1991), 23(6), 1424-1432. 10.1093/cercor/bhs125 Link to item

Nguyen, T. V., McCracken, J. T., Ducharme, S., Cropp, B. F., Botteron, K. N., Evans, A. C., & Karama, S. (2013). Interactive effects of dehydroepiandrosterone and testosterone on cortical thickness during early brain development. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 33(26), 10840-10848. 10.1523/JNEUROSCI.5747-12.2013 Link to item

Ducharme, S., Fraser, R., & Gill, K. (2012). Update on the clinical use of buprenorphine: In opioid-related disorders. Canadian Family Physician Medecin De Famille Canadien, 58(1), 37-41. 58/1/37 Link to item

Ducharme, S., Hudziak, J. J., Botteron, K. N., Albaugh, M. D., Nguyen, T. V., Karama, S., . . . Brain Development Cooperative Group. (2012). Decreased regional cortical thickness and thinning rate are associated with inattention symptoms in healthy children. Journal of the American Academy of Child and Adolescent Psychiatry, 51(1), 18-27.e2. 10.1016/j.jaac.2011.09.022 Link to item

Ducharme, S., Flaherty, A. W., Seiner, S. J., Dougherty, D. D., & Morales, O. G. (2011). Temporary interruption of deep brain stimulation for parkinson's disease during outpatient electroconvulsive therapy for major depression: A novel treatment strategy. The Journal of Neuropsychiatry and Clinical Neurosciences, 23(2), 194-197. 10.1176/appi.neuropsych.23.2.194 Link to item

Ducharme, S., Hudziak, J. J., Botteron, K. N., Ganjavi, H., Lepage, C., Collins, D. L., . . . Brain Development Cooperative Group. (2011). Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children. Biological Psychiatry, 70(3), 283-290. 10.1016/j.biopsych.2011.03.015 Link to item

Ducharme, S., & Kolivakis, T. T. (2011). Psychosis secondary to ALS in the absence of dementia: A convincing case. The Journal of Neuropsychiatry and Clinical Neurosciences, 23(3), E33. 10.1176/appi.neuropsych.23.3.E33 Link to item

The Montreal Neurological Institute & Hospital is a McGill University research and teaching institute; delivering the highest quality of care to patients, as part of the Neuroscience Mission of the McGill University Health Centre. The Neuro is proud to be a Killam Institution, supported by the Killam Trusts.