Email: ptito [at] bic.mni.mcgill.ca (Alain Ptito)
Tel.: 514-934-1934 ext. 34287
Recent Publications: PubMed
Academic Affiliations: Neurology and Neurosurgery, Psychology
Research Groups: Cognitive Neuroscience, Neural Circuits
Dr. Alain Ptito, Director of the Department of Psychology of the McGill University Health Centre, investigates the mechanisms involved in cerebral reorganization and plasticity in specific patient populations---hemispherectomy, callosotomy, Parkinson’s Disease, stroke and head injury. His clinical work includes the neuropsychological assessment of these patients. One of his principal research focus has been the effect on a patient’s vision following a hemispherectomy, the surgical removal or disconnection of a cerebral hemisphere. In recent years, Dr. Ptito has explored new methods of using fMRI and MRI (Diffusion Tensor Imaging, voxel-based morphometry) for examining brain trauma, particularly among athletes. He has carried out baseline fMRI and neuropsychological testing of varsity hockey and football athletes and repeated the tests immediately after concussion and later until symptom resolution. His results show that fMRI is sensitive enough to detect abnormal activation patterns in individuals who have suffered a concussion. Functional MRI could provide an objective way to measure the severity of a concussion and subsequent recovery. Dr. Ptito is using his findings to examine victims of other forms of traumatic brain injury such as motor vehicle accidents, falls, closed head injury and blasts in soldiers returning from combat.
Gosselin, N.*, Bottari, C., Chen, J.K., Petrides, M., Tinawi, S., de Guise, E., Ptito A. (2011) Electrophysiology and functional MRI in post-acute mild traumatic brain injury, Journal of Neurotrauma Mar;28(3):329-41.
Jubault,T., Gagnon, J-F., Karama, S., Ptito, A., Lafontaine, A-L. Evans, A.C., Monchi, O. (2011) Patterns of cortical thickness and surface area in early Parkinson’s disease. Neuroimage. Mar 15;55(2):462-7.
Ogourtsova T, Korner-Bitensky N, Ptito A. (2010) Contribution of the superior colliculi to post-stroke unilateral spatial neglect and recovery. Neuropsychologia. Jul;48(9):2407-16.
Gosselin, N., Saluja, R.S., Chen, J.K., Bottari, C., Karen, Johnston, K., Ptito, A. (2010) Brain functions after sports concussion: insights from event-related potentials and functional magnetic resonance imaging, The Physician and SportsMedicine Oct;38 (3):27-37.
Tremblay, C., Blais, J., Lachance, J., Ptito, A., Monchi, O., Monetta, L. (2010) Time-course and qualitative analysis of unconstrained oral naming abilities in non-demented Parkinson’s individuals. Rev Neuropsychol.; 2 (4) : 1-10.
Ogourtsova, T., Korner-Bitensky, N., Eskes, G., Fellows, L. & Ptito, A. Post-Stroke Unilateral Spatial Neglect: Linking animal and human research as a route to more effective intervention. Neuropsychologia (Under review).
Leh, Sandra E., Ptito, A., Schönwiesner, M., Chakravarty, M.M. & Mullen, Kathy T. (2010) Blindsight Mediated by an S-Cone-independent Collicular Pathway: An fMRI Study in Hemispherectomized Subjects. J. of Cognitive Neurosci. 22:4, pp. 670–682.
Bottari, C.**, Gosselin, N.*, Gelinas, I., Ptito A. (2010) Should we be concerned about driving after a mild traumatic brain injury? Brain injury, 24 (3), 119.
Gosselin, N.*, Bottari, C., Chen, J.K., Petrides, M., Tinawi, S., de Guise, E., Ptito, A. (2010) Electrophysiology and functional MRI reveal cerebral dysfunction after mild traumatic brain injury, Brain injury, 24 (3), 221.
Davis, G.A., Iverson, G.L., Guskiewicz, K.M., Ptito, A.., Johnston, K.M. (2009) Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion. Br. J. Sports Med. 43, Suppl.1: i36-45.
Ko, JH, Ptito, A, Monchi, O. ,So Cho, S., Van Eimeren, T., Pellecchia, G., Ballanger, B., Rusjan, P., Houle, S., & Strafella, A. (2009) Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: a [11C]FLB 457 PET study, Neuroimage, 46 (2): 516-21 (Epub).
Ptito, A. (2008) Depression in athletes that suffered concussion. Le Spécialiste. Fédération des médecins spécialistes du Québec.
Chen JK*, Johnston KM, Petrides M, Ptito A. (2008) Recovery from mild head injury in sports: Evidence from serial functional MRI studies in male athletes. Clin J Sport Med, 18, 3, 241-247.
Fraraccio, M.*, Ptito, A., Sadikot, A.F., Panisset, M., Dagher, A. (2008) Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Archives of Clinical Neuropsychology Jul;23 (4):399-408.
Lachapelle, J.**, Ptito, A. & McKerral, M. (2008) Deficits in complex visual information processing after mild TBI : electrophysiological markers and vocational outcome prognosis. Brain Injury Mar;22(3):265-74.
Ko, J.H**., Monchi, O., Ptito, A., Bloomfield, P. Houle, S. & Strafella, A.P. (2008), “Theta burst stimulation induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during set-shifting task - a TMS-[11C]raclopride PET study,” European Journal of Neuroscience, vol. 28 (10), pp. 2147–2155, November (Best Publication Award).
Ko, J.H.**, Monchi, O., Ptito, A., Petrides, M. & Strafella, A.P. (2008) Repetitive transcranial magnetic stimulation of dorsolateral prefrontal cortex during the provision of feedback, but not during set shifting, affects performance of the Wisconsin Card Sorting Task. International Journal of Biomedical Imaging. Volume 2008 Article ID 143238