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UID:20260625T064530EDT-9009upEWx0@132.216.98.100
DTSTAMP:20260625T104530Z
DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi
 on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972
 –1984)\, to constantly bridge the clinical and research realms. The talks 
 will highlight the latest advances and discoveries in neuropsychology\, co
 gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis
 ts from across The Neuro\, as well as colleagues and collaborators locally
  and from around the world. The series is intended to provide a virtual fo
 rum for scientists and trainees to continue to foster interdisciplinary ex
 changes on the mechanisms\, diagnosis and treatment of brain and cognitive
  disorders.\n\n\nRegister for In-Person\n\nTo watch online\, click here\n
 \nHost: Marco Leyton\n\n\n	\n\nDrug and Stress Effects on D2 and mGlu5 Rece
 ptors: The Transition to Addictions and Their Comorbid Disorders\n\nAbstra
 ct: Dopamine D2/3 and glutamate mGluR5 receptor systems are key regulators
  of reward learning\, stress responsivity\, and neuroplasticity\, and have
  been strongly implicated in substance use disorders (SUDs). However\, it 
 remains unclear whether receptor alterations reflect pre-existing vulnerab
 ility or consequences of substance exposure. This lecture presents longitu
 dinal PET findings from a high-risk cohort studied at ages 18 and 25 using
  [¹⁸F]fallypride (D2/3) and [¹¹C]ABP688 (mGluR5)\, alongside clinical and 
 substance use assessments. The work examines neurochemical changes occurri
 ng before and after the onset of SUD and other DSM-5 disorders\, and how t
 hese changes relate to substance use and stress. Results show that individ
 uals who later developed SUD had higher striatal D2/3 receptor availabilit
 y at age 18\, followed by marked declines by age 25\, with greater decreas
 es associated with increased alcohol use. In contrast\, mGluR5 declines we
 re observed across emerging DSM-5 disorders and were linked to drug exposu
 re and stress\, with stress effects amplified among individuals with great
 er increases in drug use. Together\, these longitudinal findings highlight
  developmental changes in dopamine and glutamate systems that help explain
  vulnerability\, neuroadaptation\, and the emergence of addiction and rela
 ted psychopathology.\n\nMaja Nikolic\n\nPhD Candidate\, McGil University\n
 \nMaja Nikolic is a PhD candidate in Neuroscience at McGill University in 
 the laboratory of Dr. Marco Leyton. Her research investigates how temperam
 ent\, early life adversity\, and mesocorticolimbic circuits interact acros
 s development to increase vulnerability to substance use disorders. She st
 udies addiction vulnerability using longitudinal PET and fMRI in a high-ri
 sk cohort\, focusing on dopamine D2/3 receptors ([18F]fallypride) and glut
 amate mGluR5 ([11C]ABP688) markers and their relationships with substance 
 use\, stress\, and emerging psychopathology. In addition\, she conducts st
 ructured clinical interviews (SCID-5) to characterize psychiatric outcomes
  and integrates clinical and neuroimaging data to model trajectories of ri
 sk and resilience.\n
DTSTART:20260223T180000Z
DTEND:20260223T190000Z
LOCATION:De Grandpré Communications Centre\, The Neuro
SUMMARY:Feindel Brain and Mind Seminar Series: Drug and Stress Effects on D
 2 and mGlu5 Receptors: The Transition to Addictions and Their Comorbid Dis
 orders
URL:https://www.mcgill.ca/neuro/channels/event/feindel-brain-and-mind-semin
 ar-series-drug-and-stress-effects-d2-and-mglu5-receptors-transition-371327
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