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DTSTAMP:20261027T050109Z
DESCRIPTION:The Annual George Karpati Lecture honours a world-renowned neur
 ologist and clinician-scientist who dedicated his remarkable career to The
  Neuro. Dr. Karpati was celebrated for advancing the diagnosis\, treatment
 \, and understanding of neuromuscular diseases\, especially muscular dystr
 ophy. Each year\, his colleagues host this lecture to highlight recent pro
 gress in neuromuscular research and care\, paying tribute to a beloved fri
 end\, mentor\, and scientific leader.\n\n\nRegister Now\n\nTo watch online
 \, click here\n\n\nThe Era of Bespoke Therapies for Genetic Neuromuscular 
 Diseases\n\nLecture Abstract: Myology has been an indispensable centerpiec
 e in our expanding understanding of basic biology\, cellular physiology\, 
 and genetics over centuries. It has also been a constant partner in develo
 pment of techniques to study cellular biology\, histopathology\, and disea
 se pathogenesis. However\, many primary disorders of skeletal muscle remai
 n recalcitrant. With the recent advent of DNA- and RNA-directed therapies\
 , a decades-long vision of treating patients with rare neuromuscular disea
 ses seems within reach\, although many barriers remain to be overcome. Thi
 s presentation will give an overview of monogenic neuromuscular disorders 
 from a physician-scientist viewpoint and provide a few concrete examples o
 f approaches in the laboratory to study disease pathomechanisms\, to ident
 ify therapeutic targets\, and to develop bespoke/precision therapies for t
 hese rare diseases.\n\nPayam Mohassel\n\n\n\nDr. Mohassel is a physician s
 cientist who specializes in myopathies\, muscular dystrophies\, and other 
 hereditary neuromuscular disorders. He is also the co-director of the John
 s Hopkins Myositis Center and a myopathologist. Dr. Mohassel obtained his 
 medical degree from the Johns Hopkins University School of Medicine\, wher
 e he remained for a medical internship\, residency training in neurology\,
  and clinical fellowship training in neuromuscular medicine. He then joine
 d the National Institute of Neurological Disorders and Stroke Neurogenetic
 s branch as a clinical research fellow under the mentorship of Prof. Carst
 en Bonnemann for 8 years\, before returning to Johns Hopkins department of
  Neurology as faculty. Dr. Mohassel’s research focuses on translational st
 udies in neurogenetic\, neuromuscular disorders\, and it spans gene discov
 ery efforts\, mechanistic studies to identify therapeutic targets\, and ea
 rly phase interventional clinical trials for rare neuromuscular diseases.
 \n
DTSTART:20260224T210000Z
DTEND:20260224T230000Z
LOCATION:De Grandpré Communications Centre\, The Neuro
SUMMARY:George Karpati Lecture: The Era of Bespoke Therapies for Genetic Ne
 uromuscular Diseases
URL:https://www.mcgill.ca/neuro/channels/event/george-karpati-lecture-era-b
 espoke-therapies-genetic-neuromuscular-diseases-367516
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