Madeleine Sharp, MD

Madeleine Sharp, MD
Contact Information
Alternate phone: 
514-398-5174
Email address: 
madeleine.sharp [at] mcgill.ca
Hospital title: 
Assistant Professor, Department of Neurology and Neurosurgery
Location: 
Movement Disorders Programme
Biography: 

Dr. Madeleine Sharp is a neurologist and clinician-scientist specializing in movements disorders at the Montreal Neurological Institute of McGill University. She received her MD from McGill University, completed her Neurology residency at the University of British Columbia and completed post-doctoral fellowship training at Columbia University. Her research focuses on understanding the cognitive mechanisms underlying cognitive and behavioural symptoms in patients with neurodegenerative disorders, in particular, Parkinson’s disease. The long-term goal is to develop a framework for understanding the many cognitive and behavioural phenotypes of Parkinson’s disease that takes into consideration genetics, pathophysiology, co-morbidities and social factors. 

Selected publications: 

Lahlou, S., Kaminska, M., Doyon, J., Carrier, J., & Sharp, M. (2024). Sleep spindle density and temporal clustering are associated with sleep-dependent memory consolidation in Parkinson’s disease. Journal of Clinical Sleep Medicine. https://doi.org/10.5664/jcsm.11080 

Balit, N., Sun, S., Zhang, Y., & Sharp, M. (2024). Online unsupervised performance-based cognitive testing: A feasible and reliable approach to scalable cognitive phenotyping of Parkinson’s patients. Parkinsonism & Related Disorders, 129, 107183. https://doi.org/10.1016/j.parkreldis.2024.107183 

Bogdanov, M., LoParco, S., Otto, A. R., & Sharp, M. (2022). Dopaminergic medication increases motivation to exert cognitive control by reducing subjective effort costs in Parkinson’s patients. Neurobiology of Learning and Memory, 193, 107652. https://doi.org/10.1016/j.nlm.2022.107652 

Lahlou, S., Gabitov, E., Owen, L., Shohamy, D., & Sharp, M. (2022). Preserved motor memory in Parkinson’s disease. Neuropsychologia, 167, 108161. https://doi.org/10.1016/j.neuropsychologia.2022.108161 

Pilgrim, M. J. D., Ou, Z.-Y. A., & Sharp, M. (2021). Exploring reward-related attention selectivity deficits in Parkinson’s disease. Scientific Reports, 11(1), 18751. https://doi.org/10.1038/s41598-021-97526-7 

Sharp, M. E., Duncan, K., Foerde, K., & Shohamy, D. (2020). Dopamine is associated with prioritization of reward-associated memories in Parkinson’s disease. Brain, 143(8), 2519–2531. https://doi.org/10.1093/brain/awaa182 

Research areas: 
Cognitive Neuroscience

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The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.

 

 

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