Eliane Kobayashi, MD, PhD
Eliane Kobayashi is a neurologist with expertise in the field of Epilepsy. Her main interests include:
- genotype-phenotype correlation in familial epilepsies, to understand how the genetic basis influence the clinical presentation and structural/functional abnormalities in patients with inherited forms of epilepsy, especially temporal lobe epilepsies.
- application of multimodal neurophysiology, structural and functional neuroimaging for the evaluation of propagation of epileptic activity and the extent of the epileptogenic network (magnetoencephalography/magnetic source imaging, combined recording of electroencephalogram and functional magnetic resonance imaging, magnetic resonance spectroscopy.
- understanding the mechanisms underlying hyperexcitability in epilepsy and their relationship with seizure vulnerability and seizure intractability (using receptor binding studies with positron emission tomography, autoradiography, immunohistochemistry and gene expression studies).
Heers M, Hedrich T, An D, Dubeau F, Gotman F, Grova C, Kobayashi E. Spatial correlation of hemodynamic changes related to interictal epileptic discharges with electric and magnetic source imaging. Human Brain Mapp 2014 Sep;35(9):4396-414. Epub 2014 Feb 24
Heers M, Chowdhury R, Hedrich T, Dubeau F, Hall JA, Lina JM, Grova C, Kobayashi E. Localization accuracy of distributed inverse solutions for electric and magnetic source imaging of interictal epileptic discharges in patients with focal epilepsy. Brain Topogr 2015 Jan 22. [Epub ahead of print].
Kobayashi E, Li LM, Lopes-Cendes I, Cendes F. Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy. Arch Neurol. 2002 Dec;59(12):1891-4.
Kobayashi E, D'Agostino MD, Lopes-Cendes I, Berkovic SF, Li M Li, Andermann E, Andermann F, Cendes F. Hippocampal atrophy and T2 weighted signal changes in familial mesial temporal lobe epilepsy. Neurology 2003 Feb 11;60(3):405-9.
Kobayashi E, Santos NF, Torres FR, Secolin R, Sardinha LA, Lopez-Cendes I, Cendes F. Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras. Arch Neurol. 2003 Nov;60(11):1546-51
Kobayashi E, Bagshaw AP, Grova C, Dubeau F, Gotman J. Negative BOLD responses to epileptic spikes. Hum Brain Mapp 2006 Jun;27(6):488-97. Epub 2005 Sep 22.
Kobayashi E, Bagshaw AP, Grova C, Gotman J, Dubeau F. Grey Matter Heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. Brain 2006 Feb;129(Pt 2):366-74. Epub 2005 Dec 9.
Kobayashi E, Bagshaw AP, Bénar CG, Aghakhani Y, Andermann F, Dubeau F, Gotman J.Temporal and extratemporal BOLD responses to temporal lobe interictal spikes. Epilepsia. 2006 Feb;47(2):343-54.