Killam Seminar Series presents "Towards a More Authentic Vision of the (multi)Coding Potential of RNA"

Tuesday, January 18, 2022 16:00to17:00

Xavier Roucou will present, “Towards a more authentic vision of the (multi)coding potential of RNA".

Registration available here.

Speaker: Xavier Roucou, PhD
Professor and Department Chair, Department of Biochemistry and Functional Genomics, Université de Sherbrooke
Canada Research Chair in Functional Proteomics and Discovery of Novel Proteins

Abstract: Ten of thousands of open reading frames (ORFs) are hidden within transcripts. They have eluded annotations because they are either small or within unsuspected locations. These are named alternative ORFs (altORFs) or small ORFs and have recently been highlighted by innovative proteogenomic approaches, such as our OpenProt resource, revealing their existence and implications in biological functions. Due to the absence of altORFs from annotations, pathogenic mutations within these are being ignored. I will discuss our latest progress on the re-analysis of large-scale proteomics datasets to improve our knowledge of proteomic diversity, and the functional characterization of a second protein coded by the FUS gene. Finally, I will explain the need to map the coding potential of the transcriptome using artificial intelligence rather than with conventional annotations that do not capture the full translational activity of ribosomes.

Supported by the generosity of the Killam Trusts , The Neuro’s Killam Seminar series hosts outstanding guest speakers whose research is of interest to the scientific community at The Neuro and McGill University.

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The Neuro (Montreal Neurological Institute-Hospital) is a bilingual academic healthcare institution. We are a McGill research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the McGill University Health Centre. We are proud to be a Killam Institution, supported by the Killam Trusts.



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