The Neuro's DJK Lecture was established in 2004 to recognize women of influence in business, science, politics or the humanities.
The 2020 Dorothy J. Killam Lecture will be delivered by Hongkui Zeng, Executive Director of Structured Science of the Allen Institute for Brain Science, Seattle, USA. Her lecture is titled "Cell type classification and circuit mapping in the mouse brain”. A reception will follow.
To understand the function of the brain and how its dysfunction leads to brain diseases, it is essential to have a deep understanding of the cell type composition of the brain, how the cell types are connected with each other and what their roles are in circuit function. At the Allen Institute, we have built multiple platforms, including single-cell transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, high throughput brain-wide connectivity mapping, and large-scale neuronal activity imaging, to characterize the transcriptomic, physiological, morphological, and connectional properties of different types of neurons in a standardized way, towards a taxonomy of cell types and a description of their wiring diagram for the mouse brain, with a focus on the visual cortico-thalamic system. Building such knowledge base lays the foundation towards the understanding of the computational mechanisms of brain circuit function.
Registration is online here.