Infectious & Inflammatory Disease Models

Our infectious disease models include a wide range of bacterial, viral, parasitic and fungal pathogens to evaluate host-pathogen interaction.

Viral pathogens

  • Influenza virus
  • Herpes Simplex virus
  • Cytomegalovirus

Bacterial pathogens

  • Salmonella enterica (gastrointestinal or systemic infection)
  • Citrobacter rodentium
  • Mycobacterium bovis - Bacillus Calmette-Guérin (BCG)

Parasitic pathogens

  • Plasmodium chabaudi (blood stage malaria)
  • Plasmodium berghei (cerebral malaria)

Fungal pathogens

  • Cryptococcus neoformans

Autoimmune and Inflammatory Disease Models

  • MOG/CFA-induced EAE (multiple sclerosis)
  • Dextran sodium sulfate (DSS)-induced colitis (colitis)

Animal models can be tailored to meet study design. We also welcome the opportunity to develop new mouse models of infectious and inflammatory diseases!

Functional and outcome analysis offered:

  • Semi-quantitative scoring
  • Body weight analysis
  • Enumeration of pathogen burden from target tissues
  • Time point studies
  • Survival analysis
  • Collection of blood and/or solid organs for downstream histopathology lesion scoring, flow cytometry, molecular and biochemical  analysis