1. Vidal, S.M., D. Malo, K. Vogan, E. Skamene, and P. Gros. 1993. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73:469-485. PMID: 8490962
  2. Qureshi, S.T., L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, P. Gros, and D. Malo. 1999. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189:615-625. PMID: 9989976
  3. Lee, S.H., S. Girard, D. Macina, M. Busa, A. Zafer, A. Belouchi, P. Gros, and S.M. Vidal. 2001. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet 28:42-45. PMID: 11326273
  4. Turcotte, K., S. Gauthier, A. Tuite, A. Mullick, D. Malo, and P. Gros. 2005. A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med 201:881-890. PMID: 15781580
  5. Arhin, F., O. Belanger, S. Ciblat, M. Dehbi, D. Delorme, E. Dietrich, D. Dixit, Y. Lafontaine, D. Lehoux, J. Liu, G.A. McKay, G. Moeck, R. Reddy, Y. Rose, R. Srikumar, K.S. Tanaka, D.M. Williams, P. Gros, J. Pelletier, T.R. Parr, Jr., and A.R. Far. 2006. A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. Bioorg Med Chem 14:5812-5832. PMID: 16759869
  6. Belley, A., M. Callejo, F. Arhin, M. Dehbi, I. Fadhil, J. Liu, G. McKay, R. Srikumar, P. Bauda, D. Bergeron, N. Ha, M. Dubow, P. Gros, J. Pelletier, and G. Moeck. 2006. Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus. Mol Microbiol 62:1132-1143. PMID: 17010157
  7. Caron, J., L. Lariviere, M. Naccache, M. Tam, M.M. Stevenson, C. McKerly, P. Gros, and D. Malo. 2006. Influence of Slc11a1 on the outcome of Salmonella enterica serovar Enteritidis infection in mice is associated with Th polarization. Infect Immun 74:2787-2802. PMID: 16622216
  8. Kwan, T., J. Liu, M. Dubow, P. Gros, and J. Pelletier. 2006. Comparative genomic analysis of 18 Pseudomonas aeruginosa bacteriophages. J Bacteriol 188:1184-1187. PMID: 16428425
  9. McKay, G.A., R. Reddy, F. Arhin, A. Belley, D. Lehoux, G. Moeck, I. Sarmiento, T.R. Parr, P. Gros, J. Pelletier, and A.R. Far. 2006. Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett 16:1286-1290. PMID: 16343901
  10. Gallant, C.J., S. Malik, N. Jabado, M. Cellier, L. Simkin, B.B. Finlay, E.A. Graviss, P. Gros, J.M. Musser, and E. Schurr. 2007. Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease. Genes Immun 8:691-698. PMID: 17917676
  11. Roy, M.F., N. Riendeau, C. Bedard, P. Helie, G. Min-Oo, K. Turcotte, P. Gros, F. Canonne-Hergaux, and D. Malo. 2007. Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice. J Exp Med 204:2949-2961. PMID: 17998386
  12. Turcotte, K., S. Gauthier, D. Malo, M. Tam, M.M. Stevenson, and P. Gros. 2007. Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens. J Immunol 179:2467-2476. PMID: 17675508
  13. Ayi, K., G. Min-Oo, L. Serghides, M. Crockett, M. Kirby-Allen, I. Quirt, P. Gros, and K.C. Kain. 2008. Pyruvate kinase deficiency and malaria. N Engl J Med 358:1805-1810. PMID: 18420493
  14. LeBlanc, P.M., G. Yeretssian, N. Rutherford, K. Doiron, A. Nadiri, L. Zhu, D.R. Green, S. Gruenheid, and M. Saleh. 2008. Caspase-12 modulates NOD signaling and regulates antimicrobial peptide production and mucosal immunity. Cell Host Microbe 3:146-157. PMID: 18329614
  15. Patel, S.N., J. Berghout, F.E. Lovegrove, K. Ayi, A. Conroy, L. Serghides, G. Min-oo, D.C. Gowda, J.V. Sarma, D. Rittirsch, P.A. Ward, W.C. Liles, P. Gros, and K.C. Kain. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205:1133-1143. PMID: 18426986
  16. Richer, E., S.T. Qureshi, S.M. Vidal, and D. Malo. 2008. Chemical mutagenesis: a new strategy against the global threat of infectious diseases. Mamm Genome 19:309-317. PMID: 18560940
  17. Vidal, S.M., D. Malo, J.F. Marquis, and P. Gros. 2008. Forward genetic dissection of immunity to infection in the mouse. Annu Rev Immunol 26:81-132. PMID: 17953509
  18. Zhang, A.S., F. Canonne-Hergaux, S. Gruenheid, P. Gros, and P. Ponka. 2008. Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Exp Hematol 36:1227-1235. PMID: 18722041
  19. Ayi, K., W.C. Liles, P. Gros, and K.C. Kain. 2009. Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro. J Infect Dis 200:1289-1299. PMID: 19743919
  20. Fortier, A., K. Doiron, M. Saleh, S. Grinstein, and P. Gros. 2009. Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun 77:4794-4805. PMID: 19720760
  21. Behr, M., E. Schurr, and P. Gros. 2010. TB: screening for responses to a vile visitor. Cell 140:615-618. PMID: 20211131
  22. Dupaul-Chicoine, J., G. Yeretssian, K. Doiron, K.S. Bergstrom, C.R. McIntire, P.M. LeBlanc, C. Meunier, C. Turbide, P. Gros, N. Beauchemin, B.A. Vallance, and M. Saleh. 2010. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32:367-378. PMID: 20226691
  23. Gruenheid, S., and P. Gros. 2010. Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories. Clin Exp Immunol 162:393-401. PMID: 21070206
  24. Min-Oo, G., K. Ayi, S.E. Bongfen, M. Tam, I. Radovanovic, S. Gauthier, H. Santiago, A.G. Rothfuchs, E. Roffe, A. Sher, A. Mullick, A. Fortin, M.M. Stevenson, K.C. Kain, and P. Gros. 2010. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. Exp Parasitol 125:315-324. PMID: 20219464
  25. Murawski, I.J., R.W. Maina, D. Malo, L.M. Guay-Woodford, P. Gros, M. Fujiwara, K. Morgan, and I.R. Gupta. 2010. The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12. Kidney Int 78:269-278. PMID: 20407478
  26. Richer, E., C. Prendergast, D.E. Zhang, S.T. Qureshi, S.M. Vidal, and D. Malo. 2010. N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-alphass signaling and suppresses STAT4-induced IFN-gamma production, resulting in increased susceptibility to Salmonella typhimurium. J Immunol 185:3593-3601. PMID: 20693420
  27. Stevenson, M.M., P. Gros, M. Olivier, A. Fortin, and L. Serghides. 2010. Cerebral malaria: human versus mouse studies. Trends Parasitol 26:274-275. PMID: 20382077
  28. Diez, E., L. Zhu, S.A. Teatero, M. Paquet, M.F. Roy, J.C. Loredo-Osti, D. Malo, and S. Gruenheid. 2011. Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice. Genes Immun 12:280-290. PMID: 21326319
  29. Teatero, S.A., J.L. Thomassin, L. Zhu, E. Diez, D. Malo, and S. Gruenheid. 2011. The Cri1 locus is the common genetic cause of susceptibility to Citrobacter rodentium infection in C3H and FVB mouse strains. Gut Microbes 2:173-177. PMID: 21804358
  30. Berghout, J., S. Higgins, C. Loucoubar, A. Sakuntabhai, K.C. Kain, and P. Gros. 2012. Genetic diversity in human erythrocyte pyruvate kinase. Genes Immun 13:98-102. PMID: 21833022
  31. Bongfen, S.E., I.G. Rodrigue-Gervais, J. Berghout, S. Torre, P. Cingolani, S.A. Wiltshire, G.A. Leiva-Torres, L. Letourneau, R. Sladek, M. Blanchette, M. Lathrop, M.A. Behr, S. Gruenheid, S.M. Vidal, M. Saleh, and P. Gros. 2012. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS One 7:e31012. PMID: 22363534
  32. Herdy, B., M. Jaramillo, Y.V. Svitkin, A.B. Rosenfeld, M. Kobayashi, D. Walsh, T. Alain, P. Sean, N. Robichaud, I. Topisirovic, L. Furic, R.J. Dowling, A. Sylvestre, L. Rong, R. Colina, M. Costa-Mattioli, J.H. Fritz, M. Olivier, E. Brown, I. Mohr, and N. Sonenberg. 2012. Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nat Immunol 13:543-550. PMID: 22544393
  33. Idaghdour, Y., J. Quinlan, J.P. Goulet, J. Berghout, E. Gbeha, V. Bruat, T. de Malliard, J.C. Grenier, S. Gomez, P. Gros, M.C. Rahimy, A. Sanni, and P. Awadalla. 2012. Evidence for additive and interaction effects of host genotype and infection in malaria. Proc Natl Acad Sci U S A 109:16786-16793. PMID: 22949651
  34. Byun, M., C.S. Ma, A. Akcay, V. Pedergnana, U. Palendira, J. Myoung, D.T. Avery, Y. Liu, A. Abhyankar, L. Lorenzo, M. Schmidt, H.K. Lim, O. Cassar, M. Migaud, F. Rozenberg, N. Canpolat, G. Aydogan, B. Fleckenstein, J. Bustamante, C. Picard, A. Gessain, E. Jouanguy, E. Cesarman, M. Olivier, P. Gros, L. Abel, M. Croft, S.G. Tangye, and J.L. Casanova. 2013. Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med 210:1743-1759. PMID: 23897980
  35. Caignard, G., G.A. Leiva-Torres, M. Leney-Greene, B. Charbonneau, A. Dumaine, N. Fodil-Cornu, M. Pyzik, P. Cingolani, J. Schwartzentruber, J. Dupaul-Chicoine, H. Guo, M. Saleh, A. Veillette, M. Lathrop, M. Blanchette, J. Majewski, A. Pearson, and S.M. Vidal. 2013. Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1. PLoS Pathog 9:e1003637. PMID: 24068938
  36. Dauphinee, S.M., M.M. Eva, K.E. Yuki, M. Herman, S.M. Vidal, and D. Malo. 2013. Characterization of two ENU-induced mutations affecting mouse skeletal morphology. G3 (Bethesda) 3:1753-1758. PMID: 23979929
  37. Flaczyk, A., C.U. Duerr, M. Shourian, E.I. Lafferty, J.H. Fritz, and S.T. Qureshi. 2013. IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans. J Immunol 191:2503-2513. PMID: 23894196
  38. Meunier, C., L. Van Der Kraak, C. Turbide, N. Groulx, I. Labouba, P. Cingolani, M. Blanchette, G. Yeretssian, A.M. Mes-Masson, M. Saleh, N. Beauchemin, and P. Gros. 2013. Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. PLoS One 8:e58733. PMID: 23516545
  39. Papapietro, O., S. Teatero, A. Thanabalasuriar, K.E. Yuki, E. Diez, L. Zhu, E. Kang, S. Dhillon, A.M. Muise, Y. Durocher, M.M. Marcinkiewicz, D. Malo, and S. Gruenheid. 2013. R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Nat Commun 4:1898. PMID: 23695692
  40. Torre, S., R. van Bruggen, J.M. Kennedy, J. Berghout, S.E. Bongfen, P. Langat, M. Lathrop, S.M. Vidal, and P. Gros. 2013. Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice. Genes Immun 14:249-257. PMID: 23594960
  41. Yuki, K.E., M.M. Eva, E. Richer, D. Chung, M. Paquet, M. Cellier, F. Canonne-Hergaux, S. Vaulont, S.M. Vidal, and D. Malo. 2013. Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS One 8:e55331. PMID: 23390527
  42. Caignard, G., M.M. Eva, R. van Bruggen, R. Eveleigh, G. Bourque, D. Malo, P. Gros, and S.M. Vidal. 2014. Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives. Genes (Basel) 5:887-925. PMID: 25268389
  43. Dauphinee, S.M., E. Richer, M.M. Eva, F. McIntosh, M. Paquet, D. Dangoor, C. Burkart, D.E. Zhang, S. Gruenheid, P. Gros, M. Behr, and D. Malo. 2014. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes Immun 15:282-292. PMID: 24807690
  44. Eva, M.M., K.E. Yuki, S.M. Dauphinee, J.A. Schwartzentruber, M. Pyzik, M. Paquet, M. Lathrop, J. Majewski, S.M. Vidal, and D. Malo. 2014. Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. J Immunol 192:259-270. PMID: 24285835
  45. Fodil, N., D. Langlais, P. Moussa, G.A. Boivin, T. Di Pietrantonio, I. Radovanovic, A. Dumaine, M. Blanchette, E. Schurr, P. Gros, and S.M. Vidal. 2014. Specific Dysregulation of IFNgamma Production by Natural Killer Cells Confers Susceptibility to Viral Infection. PLoS Pathog 10:e1004511. PMID: 25473962
  46. Kennedy, J.M., N. Fodil, S. Torre, S.E. Bongfen, J.F. Olivier, V. Leung, D. Langlais, C. Meunier, J. Berghout, P. Langat, J. Schwartzentruber, J. Majewski, M. Lathrop, S.M. Vidal, and P. Gros. 2014. CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med 10.1084/jem.20140455: PMID: 25403443
  47. Lafferty, E.I., A. Flaczyk, I. Angers, R. Homer, E. d'Hennezel, D. Malo, C.A. Piccirillo, S.M. Vidal, and S.T. Qureshi. 2014. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun 15:320-332. PMID: 24848930
  48. Lafferty, E.I., S.A. Wiltshire, S.M. Vidal, and S.T. Qureshi. 2014. UNC93B1-dependent endosomal TLR signaling regulates inflammation and mortality during Coxsackievirus B3 infection. Experimental Immunology In press:
  49. Meadows, D.N., M. Pyzik, Q. Wu, S. Torre, P. Gros, S.M. Vidal, and R. Rozen. 2014. Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant. Hum Mutat 35:594-600. PMID: 24616178
  50. Rodrigue-Gervais, I.G., K. Labbe, M. Dagenais, J. Dupaul-Chicoine, C. Champagne, A. Morizot, A. Skeldon, E.L. Brincks, S.M. Vidal, T.S. Griffith, and M. Saleh. 2014. Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival. Cell Host Microbe 15:23-35. PMID: 24439895
  51. Salem, S., D. Langlais, F. Lefebvre, G. Bourque, V. Bigley, M. Haniffa, J.L. Casanova, D. Burk, A. Berghuis, K.M. Butler, T.R. Leahy, S. Hambleton, and P. Gros. 2014. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation. Blood 10.1182/blood-2014-04-570879:PMID: 25122610
  52. Pannu, J., J.I. Belle, M. Forster, C. Duerr, L. Kane, K. Harcourt, J.H. Fritz, S. Clare, and A. Nijnik. 2014. Ubiquitin Specific Protease 21 is Dispensable for Normal Development, Hematopoiesis and Immunity. . In revision for resubmission to PLoS One