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The laboratory of Samantha Gruenheid (Department of Microbiology/Immunology) studies the pathogenesis and host response to infection with enterohemorrhagic and enteropathogenic Escherichia coli (EHEC/EPEC), a group of water and food-borne Gram-negative bacteria responsible for acute cases of diarrheal disease with potentially fatal complications. The lab studies inbred mouse strains that are either resistant or susceptible to infection with the mouse pathogen Citrobacter rodentium, a model of human infections with EHEC/EPEC. The lab uses a genetic approach to identify the genes and proteins controlling inflammatory response at the intestinal mucosa, and susceptibility to lethal infection. On the pathogen side, the laboratory studies a group of EHEC and EPEC proteins that are injected into host intestinal epithelial cells by the bacterial by Type III secretion system to interfere with host functions leading to disease. |
Gruenheid Lab Contact Information |
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