Primary Members

Dr. Blanchette

Dr. Mathieu Blanchette, PhD, Associate Professor, School of Computer Science, McGill Centre for Bioinformatics, McGill University. His lab focuses on the development of algorithmic and machine learning approaches to biological sequence analysis. He is interested in the analysis of transcriptional regulation using approaches based on comparative genomics. He also develops computational approaches to the analysis of chromosome conformation capture data.

Dr. Castagner

Dr. Bertrand Castagner obtained a Ph.D. in Chemistry at Columbia University in New York in 2004. His postdoctoral years were spent at ETH Zürich from 2005 - 2008. From 2009 - 2014 he was a Group Leader in the Institute of Pharmaceutical Sciences at ETH Zürich. He joined the Department of Pharmacology & Therapeutics at McGill in 2014 and was promoted to the rank of Associate Professor in 2020. His research focuses on the design of small-molecules and natural product analogues as novel drug candidates. He is especially interested in the chemistry and biology of inositol phosphates and carbohydrates. His group has been involved in novel strategies to inactivate the toxins responsible for the pathogenesis of Clostridioides difficile. He is also interested in the human gut microbiota and how molecules can impact its composition and metabolism, for the benefit of the host (us!).

Dr. Colmegna

Dr. Ines Colmegna, MD, is an Assistant Professor, Division of Rheumatology - Department of Medicine, McGill University Health Centre. She is an Affiliate Member in the Department of Microbiology and Immunology and a Member of the MDTC. She holds a FRSQ Chercheur-Boursier Junior 2. Her laboratory studies the impact of aging on stem cell function to understand how immune aging favors autoimmunity. Her clinical focus is rheumatoid arthritis and she is involved in National and International initiatives that relate to this disease.

Dr. Fritz

Dr. Jörg Hermann Fritz, PhD, is a CIHR New Investigator, and an Associate Professor (Departments of Microbiology and Immunology and Physiology). He is an immunologist who trained with Dr. D. Philpott (Institut Pasteur, Paris), and Dr. J. Gommerman (U. Toronto), and who joined the MRCCT in 2010. Research in his laboratory focuses on understanding how tissue homeostasis at mucosal surfaces is regulated in health and disease. A particular focus is given to studies of mucosal pathogens of the respiratory and gastrointestinal system where he is trying to understand how the expression pattern and activity of innate resistance effectors adapts to changes in the tissue milieu due to the availability of nutritional metabolites, the composition of the mutualistic microflora, or infection with pathogens. In this context he is studying the priming and function of innate lymphoid cells and B lineage cells for their role in mucosal immunity instructed to commensals, pathobionts and pathogens. He received a Career Development Award from the Austrian Academy of Sciences in 2008, and a Research Achievement Award for the research publication with the highest impact (McGill University, 2012) and a Research Scholar Junior 1 Award by the Fonds de recherche du Québec – Santé (FRQS).

Dr. Gruenheid

Dr. Samantha Gruenheid, PhD, is an Associate Professor, Department of Microbiology and Immunology, McGill University and a FRQS Senior Chercheur-Bousier. Her expertise is in the field of host-pathogen interactions, with a particular focus on intestinal infections. Dr. Gruenheid investigates bacterial virulence mechanisms and host responses to infection. Applying a genetic approach to infection with the mouse intestinal pathogen C. rodentium, her group recently discovered a new link between intestinal infection/inflammation and the regulation of tissue homeostasis by Wnt signaling.  Her lab has also made important contributions towards the elucidation of the cell biology underlying virulence mechanisms of pathogenic E. coli.

Dr. Jabado

Dr. Nada Jabado, MD, is an Associate Professor, Department of Pediatrics, McGill University Health Centre. Her research team has identified two genetic mutations involved in up to 40% of pediatric glioblastomas, a fatal cancer of the brain. They identified changes in an important gene known as histone 3.3 in a significant fraction of children and young adults with glioblastoma. This histone gene is involved in regulating the development and growth of many body tissues, particularly in the brain. These mutations partly explain why this cancer remains unresponsive to treatments. Importantly, they identify a new pathway that may represent a new therapeutic option in glioblastoma and open a more productive approach to treating this and other cancers. Her research breakthrough with Dr. Jacek Majewski (McGill University) was identified in the December 15, 2010 issue of L’actualité as one of 35 inventions that will “change everything.” This research, published in Human Mutation in 2010, demonstrated that the sequencing of one person’s exome can permit effective research into mutations indicating a genetic disease, without the need to sequence an entire genome.

Dr. Langlais

Dr. David Langlais is an Assistant Professor in the Department of Human Genetics at McGill University and Principal Investigator at the McGill University and Genome Quebec Innovation Centre. Dr Langlais completed his Ph.D. with honours in Molecular Biology in 2011 under the supervision of Dr. Jacques Drouin at the Institut de recherches cliniques de Montréal. His work revealed the complex transcriptional regulation at play in pituitary corticotrope cells that are central to the immuno-neuroendocrine interface. Using innovative genetic models, he demonstrated that corticotrope cell populations are maintained by self duplication of post-mitotic cells. Dr Langlais then pursued postdoctoral research in Dr Philippe Gros’ laboratory at McGill University where he studied the role of critical innate immunity transcription factors and participated in the characterization of new proteins involved in immune function and neuroinflammatory conditions, including cerebral malaria. Dr Langlais has received multiple awards and fellowships, including the Milstein Young Investigator Award form the International Cytokine and Interferon Society. His current research is founded on functional genomics, bioinformatics, genome editing and molecular biology methods to explain the transcriptional mechanisms involved in normal and pathological inflammation, aiming to identify and validate novel therapeutic targets for inflammatory diseases.

Dr. Malo

Dr. Danielle Malo, DVM, PhD, is a veterinarian and a Professor in the Departments of Medicine and Human Genetics and a founding member of CTG. She is a William Dawson Scholar, and received a prestigious international scholar award from Howard Hughes Medical Institute.  She uses mouse models of infection and genetic platforms to discover and characterize genes and pathways that control the host response to infection with Salmonella using mouse models of infection.  Her lab defined the genetic architecture of host response to Salmonella infection in models of acute and chronic infections, including the identification of major host gene effects (Tlr4, Pklr, Usp18, etc.). She also uses comparative genomics to identify host response to Salmonella infection in livestock populations and in nonhuman primates.

Dr. Mandl

Dr. Judith Mandl, PhD is an Assistant Professor, Department of Physiology, McGill University and a new member of the CTG.  She has an established record of productive research in cellular immunology, particularly in the biology of T cells and in their cross-talk with cells of the innate immune system at steady-state and during infection. She has made important contributions to the field of HIV pathogenesis, demonstrating the absence of ongoing type I interferon production in a natural host for SIV and its impact on downstream adaptive responses. More recently, her work has highlighted the role of interactions of T cells with self-peptides presented by MHC to both the selection of an effective T cell repertoire in the thymus and in their trafficking dynamics through peripheral lymphoid organs. Her current work focuses on T cell recirculation in mouse models of infection or immunodeficiency, making use of cutting-edge research tools that allow linking individual cell-level to population-level processes, including intravital 2-photon and confocal microscopy.

Dr. Maurice

Dr Corinne Maurice is an Assistant Professor in the Department of Microbiology and Immunology at McGill University, a Tier 2 Canada Research Chair in gut microbial physiology, and an Azrieli Global Scholar. Her work aims to identify how to manipulate the human gut microbiome for health benefits, by characterizing the active bacterial subset of the human gut microbiome and determining how bacteriophages regulate it. Her expertise in single-cell tools and metagenomics have allowed her to pioneer the FACSeq method, whereby bacterial cells with distinct activity or damage can be sorted and sequenced to better characterize functional changes in this dynamic community. By applying microbial ecology concepts and tools to the study of bacteria and phage interactions, her group is currently exploring the role of bacteriophages in health, child stunting, and adult IBD.

Dr. Nijnik

Dr. Ana Nijnik, PhD, is an Assistant Professor, Department of Physiology, McGill University. She is a Canada Research Chair Tier 2 in Hematopoiesis and a member of the CTG since 2011. She is an expert in the biology of hematopoietic stem cells, leukocyte differentiation, and mouse models. Her contributions to the field include demonstrating the essential role of DNA repair and histone deubiquitinase MYSM1 in the maintenance of hematopoietic stem cells, and analyzing the functions of Ligase IV in B cell class switching. Her CIHR-funded research program analyses the mechanisms regulating gene expression and genetic stability in hematopoiesis and immunity, and in particular the roles of the histone H2A deubiquitinase (H2A-DUB) family of chromatin interacting proteins in this system.

Dr. Olivier

Dr.Martin Olivier, PhD. The Laboratory of Martin Olivier (Departments of Medicine Microbiology/Immunology) focuses on understanding how pathogens for major global infectious diseases (Malaria, Leishmaniasis) can influence the host innate inflammatory response by manipulating the biochemical cascades involved in the regulation of phagocyte functions. Using in vitro and in vivo infectious models we are investigating how exosome microvesicles released by protozoan parasites within their blood-sucking vectors contribute to facilitate the infection and its propagation within the mammalian host. Impact of sand fly virobiome (Phlebovirus) on cutaneous leishmaniasis development and the immunological events underlying this co-infection is studied using various KO mice for major innate immune response sensors. Using our exosome biology expertize, we are interested to isolate and characterize these vesicles from various biological fluids of human affected by malaria, visceral leishmaniasis and HIV. Therefore permitting us to better understand the pathologies of these infections and to develop exosome-based biomarker diagnostics (malaria, leishmaniasis) and vaccines (leishmaniasis, schistosomiasis). Additionally, my lab is actively developing and testing new molecules capable to induce or inhibit host protein tyrosine phosphatases to block inflammatory-based pathologies or to modulate protective immune response against infectious agents.

Dr. Piccirillo

Dr. Ciriaco Piccirillo, PhD, is an Associate Professor, Department of Microbiology and Immunology, McGill University Health Centre. He is an immunologist who trained at the reputed Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). He is currently Principal Investigator of the Laboratory of Immunoregulation unit at the Research Institute of the McGill University Health Center (RI-MUHC) and co-Leader of the Infection and Immunity Axis at the RIMUHC. He is also Director of the Immunophenotyping platform at the RI-MUHC and the Director of McGill’s FOCIS Center of Excellence in Translational Immunology and Therapeutics whose mission is to support basic and clinical research in Immunology.

Dr. Qureshi

Dr. Salman T. Qureshi, MD, is an Associate Professor, Department of Medicine and Research Director at the Meakins-Christie Laboratories as well as an attending physician in the Department of Critical Care and medical director of Adult Respiratory Therapy at the McGill University Health Centre. He is a recipient of a Tier 2 Canada Research Chair in Host Response to Respiratory Infections. He uses forward genetic strategies to identify and functionally characterize the molecular determinants of susceptibility to pathogenic fungi, bacteria, and viruses that infect the lung including the identification of several loci that mediate host defense against Cryptococcus neoformans. He contributed to the initial development of an ENU mutagenesis program platform at McGill to probe host susceptibility to infectious diseases. The overall aim of his research program is to lay a foundation for the development of targeted therapies of human infectious and inflammatory disorders.

Dr. Sladek

Dr. Rob Sladek is an Associate Professor of Human Genetics and Medicine (Endocrinology) at the McGill University and Génome Québec Innovation Centre. He completed undergraduate degrees in Engineering Science and Medicine and a clinical fellowship in Endocrinology, all at the University of Toronto. His postdoctoral training explored the role of the Estrogen-related receptors in the regulation of fat metabolism (Err-alpha) and trophoblast formation (Err-beta); as well as and the application of high-throughput genomics technologies to study complex traits. He leads the Diabetes Gene Discovery Group – a project to identify risk loci for Type 2 diabetes that was sponsored by Genome Canada and Génome Québec. Rob's current research centers on developing and applying new technologies to study gene transcription networks and protein function in living cells in order to understand how genetic risk loci influencing T2D risk or the host response to tumors exert their effects.

Dr. Saleh

Dr. Maya Saleh is an Adjunct Professor in the Departments of Medicine. She joined the faculty of Medicine at McGill University in 2005. She is a McGill University Dawson Scholar, a FRSQ Chercheur-Boursier Junior 2 and a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease. Dr. Saleh's research group investigates innate immunity, inflammation and cell death mechanisms in host defense to pathogens and cancer. She is the Scientific Director of Oncoimmunology at Bordeaux University.

Dr. Vinh

Dr. Donald Vinh, MD, is an Assistant Professor, Division of Infectious Diseases and in the Division of Allergy & Clinical Immunology (Department of Medicine), as well as in the Department of Medical Microbiology, McGill University Health Centre. He is also an Affiliate member of the Department of Human Genetics. He currently holds a chercheur-boursier clinicien Junior 1 award from the Fonds de recherche du Québec-Santé (FRQS) for his translational research program focusing on defining inborn errors of immunity in humans: By combining genetic approaches with functional immunology on robustly-defined patient cohorts, his bedside-to-bench research aims to understand the molecular mechanisms that confer susceptibility to infections, particularly fungal and viral diseases. One of the main research focus of his laboratory is genetic susceptibility to fungal infections: His lab is at the forefront of defining the genetic epidemiology of CARD9 deficiency in Québec and dissection of its molecular underpinnings that have therapeutic applications, a program supported by Le Fondation du Grand Défi Pierre Lavoie and for which he was awarded the AMMI Young Investigator Award (2016). The other main focus of his program is on the discovery and characterization of combined immunodeficiency syndromes.

Dr. Waldispühl

Dr. Jérôme Waldispühl is an Associate Professor at the School of Computer Science at McGill University. He conducts research in computational molecular biology with a strong emphasis on RNA sequence/structure analysis and protein folding prediction. Recently, he also gained interests in applications of crowdsourcing and human-computing techniques in bioinformatics. He is also recognized for his pioneering work in crowdsourcing genomics. He leads the Computer Science & Biology Group at the School of Computer Science of McGill University. He holds a PhD in Computer Science from École Polytechnnique (France) and previously was a instructor in applied mathematics at the Massachusetts Institute of Technology. He is a recipient of the Tomlinson Scientist Award (2012) and the Fessenden Professorship in Science Innovation in (2013).


Back to top