1001 Decarie Blvd
RM EM23238, Bloc E
Montréal, QC H4A 3J1
Tel: (514) 934-1934 ex. 35639
ines.colmegna [at] mcgill.ca (E-mail)
Role of stem cells in rheumatoid arthritis
My lab research focuses on defining basic mechanisms accounting for the disruption of immune tolerance in patients with rheumatoid arthritis (RA). We are specifically interested in understanding the role that adult stem cells have in initiating and perpetuating this disease. Ongoing studies aim to characterize the biology of human hematopoietic and mesenchymal stem cells in patients with recent onset and established RA, the cross talk between stem cells and other immune cells, and the impact that interventions targeting stem cells have on the restoration of immune function.
- Implications of multipotent mesenchymal stromal cell aging. Stochaj U, Kodiha M, Shum-Tim D, Colmegna I. Regen Med. 2013;8(2):211-22.
- Current understanding of rheumatoid arthritis therapy. Colmegna I, Ohata BR, Menard HA. Clin Pharmacol Ther. 2012;91(4):607-20.
- Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis. Colmegna I, Pryshchep S, Oishi H, Goronzy JJ, Weyand CM. Clin Immunol. 2012; 143(1):73-82.
- Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Colmegna I, Diaz-Borjon A, Fujii H, Schaefer L, Goronzy JJ, Weyand CM. Arthritis Rheum. 2008;58(4):990-1000.