In vertebrates, the response elicited by invading pathogens involves a sophisticated interplay of cells that constitute the innate and adaptive immune systems. This concerted response – precise in its quality, magnitude and duration – is fundamental for the elimination or control of infectious agents and the repair of the affected tissue/organ. Imprecision in the response can have serious deleterious consequences including damage to host tissue or failure to eliminate the pathogen. I will present our discoveries on key biochemical checkpoints in the innate immune system that define the activation threshold and intensity of the consequent antigen-specific adaptive immune responses. I will also discuss how these checkpoints trigger the resolution of inflammation and induction of tissue repair.
This event is co-hosted by the McGill Department of Microbiology and Immunology.